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dc.contributor.authorKoudelka, Stepan
dc.contributor.authorMasek, Josef
dc.contributor.authorNeuzil, Jiri
dc.contributor.authorTuranek, Jaroslav
dc.date.accessioned2017-05-03T14:48:35Z
dc.date.available2017-05-03T14:48:35Z
dc.date.issued2010
dc.date.modified2011-01-25T02:21:33Z
dc.identifier.issn0022-3549
dc.identifier.doi10.1002/jps.22002
dc.identifier.urihttp://hdl.handle.net/10072/35681
dc.description.abstracta-Tocopheryl succinate (a-TOS) is a semisynthetic analogue of a-tocopherol with selective toxicity to the cancer cells and anticancer activity in vivo. Yet, no suitable formulation of a-TOS for medical application has been reported. Various formulations, for example, solutions in organic solvents, oil emulsions and vesicules prepared by spontaneous vesiculation, polyethylene glycol conjugates and liposomes of various compositions have been tested. We developed and characterised a stable lyophilised liposome-based a-TOS formulation. a-TOS (15?mol%) was incorporated into large oligolamellar vesicles (OLVs) composed of soy phosphatidylcholine (SPC) by the method of lipid film hydration followed by extrusion through polycarbonate filters. Stabilised liposomal formulation was prepared by lyophilisation in the presence of sucrose (molar ratio lipid/sucrose, 1:5). The size distribution of the liposomes (130-140?nm, polydispersity index 0.14) as well as the stable lipid and a-TOS contents were preserved during storage in the lyophilised form at 2-8àfor at least 6 months. The data indicate good physical and chemical stability of the lyophilised preparation of a-TOS liposomes that can be used in clinical medicine.
dc.description.peerreviewedYes
dc.description.publicationstatusYes
dc.languageEnglish
dc.language.isoeng
dc.publisherJohn Wiley & Sons
dc.publisher.placeUnited States
dc.relation.ispartofstudentpublicationN
dc.relation.ispartofpagefrom2434
dc.relation.ispartofpageto2443
dc.relation.ispartofissue5
dc.relation.ispartofjournalJournal of Pharmaceutical Sciences
dc.relation.ispartofvolume99
dc.rights.retentionY
dc.subject.fieldofresearchPharmacology and Pharmaceutical Sciences not elsewhere classified
dc.subject.fieldofresearchPharmacology and Pharmaceutical Sciences
dc.subject.fieldofresearchcode111599
dc.subject.fieldofresearchcode1115
dc.titleLyophilised liposome-based formulations of α-tocopheryl succinate: Preparation and physico-chemical characterisation
dc.typeJournal article
dc.type.descriptionC1 - Articles
dc.type.codeC - Journal Articles
gro.date.issued2010
gro.hasfulltextNo Full Text
gro.griffith.authorNeuzil, Jiri


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