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dc.contributor.authorPetcu, EB
dc.contributor.authorSmith, RA
dc.contributor.authorMiroiu, RI
dc.contributor.authorOpris, MM
dc.date.accessioned2017-05-03T13:09:19Z
dc.date.available2017-05-03T13:09:19Z
dc.date.issued2010
dc.date.modified2011-01-25T02:22:09Z
dc.identifier.issn2040-2384
dc.identifier.doi10.1186/2040-2384-2-26
dc.identifier.urihttp://hdl.handle.net/10072/35701
dc.description.abstractAngiogenesis represents a form of neovascularisation of exceptional importance in numerous pathological conditions including stroke. In this context it is directly related to neuroregeneration which is seen in close proximity. However, numerous experimental data have been drawn from studies that have ignored the age criterion. This is extremely important as angiogenesis is different in young versus old subjects. Extrapolating data obtained from studies performed in young subjects or "in vitro" to old-age patients could lead to inexact conclusions since the dynamics of angiogenesis is age-dependent. The current review covers the key features of brain senescence including morphological and functional changes related to the brain parenchyma, its vascular network and blood flow which could possibly influence the process of angiogenesis. This is followed by a description of post-stroke angiogenesis and its relationship to neuroregeneration and its modulation by vascular endothelial growth factor (VEGF) and insulin-like growth factor 1 (IGF 1), the most important factors active in old brain after ischemic injury.
dc.description.peerreviewedYes
dc.description.publicationstatusYes
dc.format.extent1749701 bytes
dc.format.mimetypeapplication/pdf
dc.languageEnglish
dc.language.isoeng
dc.publisherBioMed Central
dc.publisher.placeUnited Kingdom
dc.relation.ispartofstudentpublicationN
dc.relation.ispartofpagefrom1
dc.relation.ispartofpageto10
dc.relation.ispartofjournalJournal of Angiogenesis Research
dc.relation.ispartofvolume2
dc.rights.retentionY
dc.subject.fieldofresearchCardiology (incl. cardiovascular diseases)
dc.subject.fieldofresearchcode320101
dc.titleAngiogenesis in old-aged subjects after ischemic stroke: a cautionary note for investigators
dc.typeJournal article
dc.type.descriptionC1 - Articles
dc.type.codeC - Journal Articles
dcterms.licensehttp://creativecommons.org/licenses/by/2.0
gro.facultyGriffith Health, School of Medicine
gro.rights.copyright© 2010 Petcu et al; licensee BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
gro.date.issued2010
gro.hasfulltextFull Text
gro.griffith.authorSmith, Robert A.
gro.griffith.authorPetcu, Eugen B.


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