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dc.contributor.authorBarclay, Chrisen_US
dc.contributor.authorWidén, C.en_US
dc.date.accessioned2017-05-03T14:49:36Z
dc.date.available2017-05-03T14:49:36Z
dc.date.issued2010en_US
dc.date.modified2011-01-27T06:45:17Z
dc.identifier.issn00652598en_US
dc.identifier.doi10.1007/978-1-4419-6366-6_15en_AU
dc.identifier.urihttp://hdl.handle.net/10072/35810
dc.description.abstractThe aim of this study was to make cellular-level measurements of the mechanical efficiency of mouse cardiac muscle and to use these measurements to determine (1) the work performed by a cross-bridge in one ATP-splitting cycle and (2) the fraction of the free energy available in metabolic substrates that is transferred by oxidative phosphorylation to free energy in ATP (i.e. mitochondrial thermodynamic efficiency). Experiments were performed using isolated left ventricular mouse papillary muscles (n=9; studied at 27é and the myothermic technique. The production of work and heat was measured during and after 40 contractions at a contraction frequency of 2 Hz. Each contraction consisted of a brief isometric period followed by isovelocity shortening. Work output, heat output and enthalpy output were all independent of shortening velocity. Maximum initial mechanical efficiency (meanᓅM) was 31.1ᱮ3% and maximum net mechanical efficiency 16.9ᱮ5%. It was calculated that the maximum work per cross-bridge cycle was 20 zJ, comparable to values for mouse skeletal muscle, and that mitochondrial thermodynamic efficiency was 72%. Analysis of data in the literature suggests that mitochondrial efficiency of cardiac muscle from other species is also likely to be between 70 and 80%.en_US
dc.description.peerreviewedYesen_US
dc.description.publicationstatusYesen_AU
dc.languageEnglishen_US
dc.language.isoen_AU
dc.publisherSpringeren_US
dc.publisher.placeUnited Statesen_US
dc.relation.ispartofstudentpublicationNen_AU
dc.relation.ispartofpagefrom267en_US
dc.relation.ispartofpageto278en_US
dc.relation.ispartofjournalAdvances in Experimental Medicine and Biologyen_US
dc.relation.ispartofvolume682en_US
dc.rights.retentionYen_AU
dc.subject.fieldofresearchMedical and Health Sciences not elsewhere classifieden_US
dc.subject.fieldofresearchcode119999en_US
dc.titleEfficiency of Cross-Bridges and Mitochondria in Mouse Cardiac Muscleen_US
dc.typeJournal articleen_US
dc.type.descriptionC1 - Peer Reviewed (HERDC)en_US
dc.type.codeC - Journal Articlesen_US
gro.facultyGriffith Health, School of Rehabilitation Sciencesen_US
gro.date.issued2010
gro.hasfulltextNo Full Text


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