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  • Parasite annexins - New molecules with potential for drug and vaccine development

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    Author(s)
    Hofmann, Andreas
    Osman, Asiah
    Leow, Chiuan Yee
    Driguez, Patrick
    McManus, Donald P
    Jones, Malcolm K
    Griffith University Author(s)
    McManus, Don P.
    Hofmann, Andreas
    Osman, Asiah
    Jones, Malcolm K.
    Year published
    2010
    Metadata
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    Abstract
    In the last few years, annexins have been discovered in several nematodes and other parasites, and distinct differences between the parasite annexins and those of the hosts make them potentially attractive targets for anti-parasite therapeutics. Annexins are ubiquitous proteins found in almost all organisms across all kingdoms. Here, we present an overview of novel annexins from parasitic organisms, and summarize their phylogenetic and biochemical properties, with a view to using them as drug or vaccine targets. Building on structural and biological information that has been accumulated for mammalian and plant annexins, we ...
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    In the last few years, annexins have been discovered in several nematodes and other parasites, and distinct differences between the parasite annexins and those of the hosts make them potentially attractive targets for anti-parasite therapeutics. Annexins are ubiquitous proteins found in almost all organisms across all kingdoms. Here, we present an overview of novel annexins from parasitic organisms, and summarize their phylogenetic and biochemical properties, with a view to using them as drug or vaccine targets. Building on structural and biological information that has been accumulated for mammalian and plant annexins, we describe a predicted additional secondary structure element found in many parasite annexins that may confer unique functional properties, and present a specific antigenic epitope for use as a vaccine.
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    Journal Title
    BioEssays
    Volume
    32
    Issue
    11
    DOI
    https://doi.org/10.1002/bies.200900195
    Copyright Statement
    © 2010 Wiley Periodicals, Inc. This is the pre-peer reviewed version of the following article: Parasite annexins - new molecules with potential for drug and vaccine development, BioEssays Volume 32, Issue 11, pages 967–976, November 2010, which has been published in final form at http://dx.doi.org/10.1002/bies.200900195
    Subject
    Biological sciences
    Proteomics and intermolecular interactions (excl. medical proteomics)
    Biomedical and clinical sciences
    Psychology
    Publication URI
    http://hdl.handle.net/10072/35921
    Collection
    • Journal articles

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