Parasite annexins - New molecules with potential for drug and vaccine development
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In the last few years, annexins have been discovered in several nematodes and other parasites, and distinct differences between the parasite annexins and those of the hosts make them potentially attractive targets for anti-parasite therapeutics. Annexins are ubiquitous proteins found in almost all organisms across all kingdoms. Here, we present an overview of novel annexins from parasitic organisms, and summarize their phylogenetic and biochemical properties, with a view to using them as drug or vaccine targets. Building on structural and biological information that has been accumulated for mammalian and plant annexins, we describe a predicted additional secondary structure element found in many parasite annexins that may confer unique functional properties, and present a specific antigenic epitope for use as a vaccine.
Copyright 2010 Wiley Periodicals, Inc. This is the pre-peer reviewed version of the following article: Parasite annexins - new molecules with potential for drug and vaccine development, BioEssays Volume 32, Issue 11, pages 967–976, November 2010, which has been published in final form at http://dx.doi.org/10.1002/bies.200900195
Proteomics and Intermolecular Interactions (excl. Medical Proteomics)