3-Alkylthio-1, 2, 4-triazine dimers with potent antimalarial activity
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We report on the discovery of 3-alkylthio-1,2,4-triazine dimers that are potently toxic to Plasmodium falciparum, with single digit nanomolar activity, and up to several thousand-fold lower toxicity to mammalian cells. They are equipotent against chloroquine-resistant strains of P. falciparum.
Bioorganic & Medicinal Chemistry Letters
Biochemistry and Cell Biology not elsewhere classified