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  • 3-Alkylthio-1, 2, 4-triazine dimers with potent antimalarial activity

    Author
    Ban, Kung
    Duffy, Sandra
    Khakhama, Yelena
    Avery, Vicky
    Hughes, Andrew
    Montagnat, Oliver
    Katneni, Kasiram
    Ryan, Eileen
    B. Baell, Jonathan
    Year published
    2010
    Metadata
    Show full item record
    Abstract
    We report on the discovery of 3-alkylthio-1,2,4-triazine dimers that are potently toxic to Plasmodium falciparum, with single digit nanomolar activity, and up to several thousand-fold lower toxicity to mammalian cells. They are equipotent against chloroquine-resistant strains of P. falciparum.We report on the discovery of 3-alkylthio-1,2,4-triazine dimers that are potently toxic to Plasmodium falciparum, with single digit nanomolar activity, and up to several thousand-fold lower toxicity to mammalian cells. They are equipotent against chloroquine-resistant strains of P. falciparum.
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    Journal Title
    Bioorganic & Medicinal Chemistry Letters
    Volume
    20
    Issue
    20
    DOI
    https://doi.org/10.1016/j.bmcl.2010.08.065
    Subject
    Biochemistry and Cell Biology not elsewhere classified
    Publication URI
    http://hdl.handle.net/10072/35925
    Collection
    • Journal articles

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