3-Alkylthio-1, 2, 4-triazine dimers with potent antimalarial activity

We report on the discovery of 3-alkylthio-1,2,4-triazine dimers that are potently toxic to Plasmodium falciparum, with single digit nanomolar activity, and up to several thousand-fold lower toxicity to mammalian cells. They are equipotent against chloroquine-resistant strains of P. falciparum.We report on the discovery of 3-alkylthio-1,2,4-triazine dimers that are potently toxic to Plasmodium falciparum, with single digit nanomolar activity, and up to several thousand-fold lower toxicity to mammalian cells. They are equipotent against chloroquine-resistant strains of P. falciparum.
View less >

Journal Title

Bioorganic & Medicinal Chemistry Letters

Volume

Issue

DOI

https://doi.org/10.1016/j.bmcl.2010.08.065

Subject

Biochemistry and Cell Biology not elsewhere classified

Publication URI

http://hdl.handle.net/10072/35925

Collection

Journal articles