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dc.contributor.authorDavis, Rohanen_US
dc.contributor.authorDuffy, Sandraen_US
dc.contributor.authorAvery, Vickyen_US
dc.contributor.authorCamp, Daviden_US
dc.contributor.authorN.A. Hooper, Johnen_US
dc.contributor.authorQuinn, Ronalden_US
dc.date.accessioned2017-05-03T14:32:52Z
dc.date.available2017-05-03T14:32:52Z
dc.date.issued2010en_US
dc.date.modified2011-02-02T06:55:05Z
dc.identifier.issn00404039en_US
dc.identifier.doi10.1016/j.tetlet.2009.11.055en_AU
dc.identifier.urihttp://hdl.handle.net/10072/35929
dc.description.abstractMass-directed isolation of the CH2Cl2/MeOH extract from the Australian marine sponge Ancorina sp. resulted in the purification of a new antimalarial ߭carboline, (+)-7-bromotrypargine 1, along with the previously isolated natural product, 6-bromotryptamine 2. The structure of 1 is determined by extensive 1D/2D NMR and MS data analyses. Comparison of the chiro-optical data for 1 with literature values of related natural products is used to determine the absolute stereochemistry of (+)-7-bromotrypargine as 1R. Antimalarial activity data for 1 and 2 against a chloroquine-resistant (Dd2) and chloroquine-sensitive (3D7) Plasmodium falciparum strain are also provided.en_US
dc.description.peerreviewedYesen_US
dc.description.publicationstatusYesen_AU
dc.languageEnglishen_US
dc.language.isoen_AU
dc.publisherElsevieren_US
dc.publisher.placeUnited Kingdomen_US
dc.relation.ispartofstudentpublicationNen_AU
dc.relation.ispartofpagefrom583en_US
dc.relation.ispartofpageto585en_US
dc.relation.ispartofissue4en_US
dc.relation.ispartofjournalTetrahedron Lettersen_US
dc.relation.ispartofvolume51en_US
dc.rights.retentionYen_AU
dc.subject.fieldofresearchBiologically Active Moleculesen_US
dc.subject.fieldofresearchcode030401en_US
dc.title(+)-7-Bromotrypargine: an antimalarial b-carboline from the Australian marine sponge Ancorina sp.en_US
dc.typeJournal articleen_US
dc.type.descriptionC1 - Peer Reviewed (HERDC)en_US
dc.type.codeC - Journal Articlesen_US
gro.date.issued2010
gro.hasfulltextNo Full Text


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