Antitrypanosomal pyridoacridine alkaloids from the Australian ascidian Polysyncraton echinatum
Author(s)
Feng, Yunjiang
Davis, Rohan A
Sykes, Melissa L
Avery, Vicky M
Carroll, Anthony R
Camp, David
Quinn, Ronald J
Griffith University Author(s)
Year published
2010
Metadata
Show full item recordAbstract
Bioassay-guided fractionation of the crude CH2Cl2/MeOH extract from the Australian ascidian Polysyncraton echinatum led to the isolation of a new pyridoacridine alkaloid, 12-deoxyascididemin (1), along with two known analogues, ascididemin (2) and eilatin (3). The structure of 1 was determined following extensive analysis of 1D/2D NMR and MS data. Biological evaluation showed that compounds 1-3 are potent antitrypanosomal agents with IC50 values of 0.077, 0.032, and 1.33 占against Trypanosoma brucei brucei, respectively.Bioassay-guided fractionation of the crude CH2Cl2/MeOH extract from the Australian ascidian Polysyncraton echinatum led to the isolation of a new pyridoacridine alkaloid, 12-deoxyascididemin (1), along with two known analogues, ascididemin (2) and eilatin (3). The structure of 1 was determined following extensive analysis of 1D/2D NMR and MS data. Biological evaluation showed that compounds 1-3 are potent antitrypanosomal agents with IC50 values of 0.077, 0.032, and 1.33 占against Trypanosoma brucei brucei, respectively.
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Journal Title
Tetrahedron Letters
Volume
51
Issue
18
Subject
Medicinal and biomolecular chemistry
Biologically active molecules
Organic chemistry
Biochemistry and cell biology