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Antitrypanosomal Cyclic Polyketide Peroxides from the Australian Marine Sponge Plakortis sp.

dc.contributor.authorFeng, Yunjiang
dc.contributor.authorDavis, Rohan A
dc.contributor.authorSykes, Melissa
dc.contributor.authorAvery, Vicky M
dc.contributor.authorCamp, David
dc.contributor.authorQuinn, Ronald J
dc.date.accessioned2017-05-03T14:32:53Z
dc.date.available2017-05-03T14:32:53Z
dc.date.issued2010
dc.date.modified2011-02-02T06:55:09Z
dc.identifier.issn0163-3864
dc.identifier.doi10.1021/np900535z
dc.identifier.urihttp://hdl.handle.net/10072/35931
dc.description.abstractBioassay-guided fractionation of the crude extract from the Australian marine sponge Plakortis sp. led to the isolation of two new cyclic polyketide peroxides, 11,12-didehydro-13-oxo-plakortide Q (1) and 10-carboxy-11,12,13,14-tetranor-plakortide Q (2). Antitrypanosomal studies showed that compound 1 had an IC50 value of 49 nM against Trypanosoma brucei brucei, and compound 2, where a carboxylic acid is present in the side chain, had a 20-fold reduction of activity. 11,12-Didehydro-13-oxo-plakortide Q (1) is the most active peroxide isolated so far against T. b. brucei, and it indicates the potential therapeutic value of this class of compounds.
dc.description.peerreviewedYes
dc.description.publicationstatusYes
dc.languageEnglish
dc.language.isoeng
dc.publisherAmerican Chemical Society
dc.publisher.placeUnited States
dc.relation.ispartofstudentpublicationN
dc.relation.ispartofpagefrom716
dc.relation.ispartofpageto719
dc.relation.ispartofissue4
dc.relation.ispartofjournalJournal of Natural Products
dc.relation.ispartofvolume73
dc.rights.retentionY
dc.subject.fieldofresearchChemical sciences
dc.subject.fieldofresearchBiologically active molecules
dc.subject.fieldofresearchBiological sciences
dc.subject.fieldofresearchBiomedical and clinical sciences
dc.subject.fieldofresearchcode34
dc.subject.fieldofresearchcode340401
dc.subject.fieldofresearchcode31
dc.subject.fieldofresearchcode32
dc.titleAntitrypanosomal Cyclic Polyketide Peroxides from the Australian Marine Sponge Plakortis sp.
dc.typeJournal article
dc.type.descriptionC1 - Articles
dc.type.codeC - Journal Articles
gro.rights.copyrightSelf-archiving of the author-manuscript version is not yet supported by this journal. Please refer to the journal link for access to the definitive, published version or contact the authors for more information.
gro.date.issued2010
gro.hasfulltextNo Full Text
gro.griffith.authorQuinn, Ronald J.
gro.griffith.authorDavis, Rohan A.
gro.griffith.authorSykes, Melissa L.
gro.griffith.authorAvery, Vicky M.
gro.griffith.authorFeng, Yun J.


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