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dc.contributor.authorDavis, Rohan A
dc.contributor.authorDemirkiran, Ozlem
dc.contributor.authorSykes, Melissa L
dc.contributor.authorAvery, Vicky M
dc.contributor.authorSuraweera, Lekha
dc.contributor.authorFechner, Gregory A
dc.contributor.authorQuinn, Ronald J
dc.date.accessioned2018-09-19T01:30:44Z
dc.date.available2018-09-19T01:30:44Z
dc.date.issued2010
dc.date.modified2011-02-02T06:55:55Z
dc.identifier.issn0960-894X
dc.identifier.doi10.1016/j.bmcl.2010.05.091
dc.identifier.urihttp://hdl.handle.net/10072/35941
dc.description.abstractMass-directed isolation of the CH2Cl2/MeOH extract from the leaves of Cryptocarya obovata resulted in the purification of a new trypanocidal a-pyrone, 7',8'-dihydroobolactone (1). The chemical structure of 1 was determined by 1D/2D NMR, MS and CD data analysis. 7',8'-Dihydroobolactone was shown to inhibit Trypanosoma brucei brucei with an IC50 of 2.8 卮
dc.description.peerreviewedYes
dc.description.publicationstatusYes
dc.languageEnglish
dc.language.isoeng
dc.publisherPergamon
dc.publisher.placeUnited Kingdom
dc.relation.ispartofstudentpublicationN
dc.relation.ispartofpagefrom4057
dc.relation.ispartofpageto4059
dc.relation.ispartofissue14
dc.relation.ispartofjournalBioorganic & Medicinal Chemistry Letters
dc.relation.ispartofvolume20
dc.rights.retentionY
dc.subject.fieldofresearchMedicinal and biomolecular chemistry
dc.subject.fieldofresearchBiologically active molecules
dc.subject.fieldofresearchOrganic chemistry
dc.subject.fieldofresearchPharmacology and pharmaceutical sciences
dc.subject.fieldofresearchcode3404
dc.subject.fieldofresearchcode340401
dc.subject.fieldofresearchcode3405
dc.subject.fieldofresearchcode3214
dc.title7′,8′-Dihydroobolactone, a typanocidal α-pyrone from the rainforest tree Cryptocarya obovata
dc.typeJournal article
dc.type.descriptionC1 - Articles
dc.type.codeC - Journal Articles
gro.date.issued2010
gro.hasfulltextNo Full Text
gro.griffith.authorQuinn, Ronald J.
gro.griffith.authorSuraweera, Lekha L.
gro.griffith.authorDavis, Rohan A.
gro.griffith.authorFechner, Gregory A.
gro.griffith.authorSykes, Melissa L.
gro.griffith.authorAvery, Vicky M.


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