dc.contributor.author | Yang, Xinzhou | |
dc.contributor.author | Davis, Rohan A | |
dc.contributor.author | Buchanan, Malcolm S | |
dc.contributor.author | Duffy, Sandra | |
dc.contributor.author | Avery, Vicky M | |
dc.contributor.author | Camp, David | |
dc.contributor.author | Quinn, Ronald J | |
dc.date.accessioned | 2021-07-26T23:48:55Z | |
dc.date.available | 2021-07-26T23:48:55Z | |
dc.date.issued | 2010 | |
dc.date.modified | 2011-02-02T06:55:56Z | |
dc.identifier.issn | 0163-3864 | |
dc.identifier.doi | 10.1021/np900834g | |
dc.identifier.uri | http://hdl.handle.net/10072/35942 | |
dc.description.abstract | A drug discovery program aimed at identifying new antimalarial leads from a prefractionated natural product library has resulted in the identification of a new bromotyrosine alkaloid, psammaplysin G (1), along with the previously isolated compound, psammaplysin F (2). When tested against two different strains of the parasite Plasmodium falciparum (Dd2 and 3D7), 2 displayed IC50 values of 1.4 and 0.87 μM, respectively, while 1 showed 98% inhibition at 40 μM against the chloroquine-resistant (Dd2) strain of P. falciparum. | |
dc.description.peerreviewed | Yes | |
dc.description.publicationstatus | Yes | |
dc.language | English | |
dc.language.iso | eng | |
dc.publisher | American Chemical Society | |
dc.publisher.place | United States | |
dc.relation.ispartofstudentpublication | N | |
dc.relation.ispartofpagefrom | 985 | |
dc.relation.ispartofpageto | 987 | |
dc.relation.ispartofissue | 5 | |
dc.relation.ispartofjournal | Journal of Natural Products | |
dc.relation.ispartofvolume | 73 | |
dc.rights.retention | Y | |
dc.subject.fieldofresearch | Chemical sciences | |
dc.subject.fieldofresearch | Biologically active molecules | |
dc.subject.fieldofresearch | Biological sciences | |
dc.subject.fieldofresearch | Biomedical and clinical sciences | |
dc.subject.fieldofresearch | Traditional, complementary and integrative medicine | |
dc.subject.fieldofresearchcode | 34 | |
dc.subject.fieldofresearchcode | 340401 | |
dc.subject.fieldofresearchcode | 31 | |
dc.subject.fieldofresearchcode | 32 | |
dc.subject.fieldofresearchcode | 4208 | |
dc.title | Antimalarial Bromotyrosine Derivatives from the Australian Marine Sponge Hyattella sp. | |
dc.type | Journal article | |
dc.type.description | C1 - Articles | |
dc.type.code | C - Journal Articles | |
dc.description.version | Accepted Manuscript (AM) | |
gro.rights.copyright | This document is the Accepted Manuscript version of a Published Work that appeared in final form in Journal of Natural Products, copyright 2010 American Chemical Society after peer review and technical editing by the publisher. To access the final edited and published work see https://doi.org/10.1021/np900834g | |
gro.date.issued | 2010 | |
gro.hasfulltext | Full Text | |
gro.griffith.author | Quinn, Ronald J. | |
gro.griffith.author | Davis, Rohan A. | |
gro.griffith.author | Duffy, Sandra | |
gro.griffith.author | Avery, Vicky M. | |