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dc.contributor.authorYang, Xinzhou
dc.contributor.authorDavis, Rohan A
dc.contributor.authorBuchanan, Malcolm S
dc.contributor.authorDuffy, Sandra
dc.contributor.authorAvery, Vicky M
dc.contributor.authorCamp, David
dc.contributor.authorQuinn, Ronald J
dc.date.accessioned2021-07-26T23:48:55Z
dc.date.available2021-07-26T23:48:55Z
dc.date.issued2010
dc.date.modified2011-02-02T06:55:56Z
dc.identifier.issn0163-3864
dc.identifier.doi10.1021/np900834g
dc.identifier.urihttp://hdl.handle.net/10072/35942
dc.description.abstractA drug discovery program aimed at identifying new antimalarial leads from a prefractionated natural product library has resulted in the identification of a new bromotyrosine alkaloid, psammaplysin G (1), along with the previously isolated compound, psammaplysin F (2). When tested against two different strains of the parasite Plasmodium falciparum (Dd2 and 3D7), 2 displayed IC50 values of 1.4 and 0.87 μM, respectively, while 1 showed 98% inhibition at 40 μM against the chloroquine-resistant (Dd2) strain of P. falciparum.
dc.description.peerreviewedYes
dc.description.publicationstatusYes
dc.languageEnglish
dc.language.isoeng
dc.publisherAmerican Chemical Society
dc.publisher.placeUnited States
dc.relation.ispartofstudentpublicationN
dc.relation.ispartofpagefrom985
dc.relation.ispartofpageto987
dc.relation.ispartofissue5
dc.relation.ispartofjournalJournal of Natural Products
dc.relation.ispartofvolume73
dc.rights.retentionY
dc.subject.fieldofresearchChemical sciences
dc.subject.fieldofresearchBiologically active molecules
dc.subject.fieldofresearchBiological sciences
dc.subject.fieldofresearchBiomedical and clinical sciences
dc.subject.fieldofresearchcode34
dc.subject.fieldofresearchcode340401
dc.subject.fieldofresearchcode31
dc.subject.fieldofresearchcode32
dc.titleAntimalarial Bromotyrosine Derivatives from the Australian Marine Sponge Hyattella sp.
dc.typeJournal article
dc.type.descriptionC1 - Articles
dc.type.codeC - Journal Articles
dc.description.versionAccepted Manuscript (AM)
gro.rights.copyrightThis document is the Accepted Manuscript version of a Published Work that appeared in final form in Journal of Natural Products, copyright 2010 American Chemical Society after peer review and technical editing by the publisher. To access the final edited and published work see https://doi.org/10.1021/np900834g
gro.date.issued2010
gro.hasfulltextFull Text
gro.griffith.authorQuinn, Ronald J.
gro.griffith.authorCamp, David B.
gro.griffith.authorBuchanan, Malcolm S.
gro.griffith.authorDavis, Rohan A.
gro.griffith.authorDuffy, Sandra
gro.griffith.authorAvery, Vicky M.
gro.griffith.authorYang, Xinzhou


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