CD4+ T cells reduce the tissue burden of Chlamydia muridarum in male BALB/c mice
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Male chlamydial infections are becoming more recognised as an aetiological agent in infertility. An IFN-? response is required for protection against Chlamydia in females, but may have the potential to induce pathology in the immune-privileged male reproductive tract. We examined the induction of immunity following intranasal immunisation with major outer membrane protein (MOMP) of Chlamydia muridarum in male BALB/c mice, and the role of MOMP-specific CD4+ T cells in clearance of an intrapenile infection. Here we report that adoptive transfer of MOMP-specific CD4+ T cells into naﶥ mice confers partial protective immunity, which significantly reduces the tissue burden of Chlamydia.
Copyright 2010 Elsevier. This is the author-manuscript version of this paper. Reproduced in accordance with the copyright policy of the publisher. Please refer to the journal's website for access to the definitive, published version.
Immunology not elsewhere classified