CD4+ T cells reduce the tissue burden of Chlamydia muridarum in male BALB/c mice

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Author(s)
A. Cunningham, Kelly
J. Carey, Alison
Timms, Peter
W. Beagley, Kenneth
Griffith University Author(s)
Year published
2010
Metadata
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Male chlamydial infections are becoming more recognised as an aetiological agent in infertility. An IFN-? response is required for protection against Chlamydia in females, but may have the potential to induce pathology in the immune-privileged male reproductive tract. We examined the induction of immunity following intranasal immunisation with major outer membrane protein (MOMP) of Chlamydia muridarum in male BALB/c mice, and the role of MOMP-specific CD4+ T cells in clearance of an intrapenile infection. Here we report that adoptive transfer of MOMP-specific CD4+ T cells into naﶥ mice confers partial protective immunity, ...
View more >Male chlamydial infections are becoming more recognised as an aetiological agent in infertility. An IFN-? response is required for protection against Chlamydia in females, but may have the potential to induce pathology in the immune-privileged male reproductive tract. We examined the induction of immunity following intranasal immunisation with major outer membrane protein (MOMP) of Chlamydia muridarum in male BALB/c mice, and the role of MOMP-specific CD4+ T cells in clearance of an intrapenile infection. Here we report that adoptive transfer of MOMP-specific CD4+ T cells into naﶥ mice confers partial protective immunity, which significantly reduces the tissue burden of Chlamydia.
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View more >Male chlamydial infections are becoming more recognised as an aetiological agent in infertility. An IFN-? response is required for protection against Chlamydia in females, but may have the potential to induce pathology in the immune-privileged male reproductive tract. We examined the induction of immunity following intranasal immunisation with major outer membrane protein (MOMP) of Chlamydia muridarum in male BALB/c mice, and the role of MOMP-specific CD4+ T cells in clearance of an intrapenile infection. Here we report that adoptive transfer of MOMP-specific CD4+ T cells into naﶥ mice confers partial protective immunity, which significantly reduces the tissue burden of Chlamydia.
View less >
Journal Title
Vaccine
Volume
28
Issue
31
Copyright Statement
© 2010 Elsevier. This is the author-manuscript version of this paper. Reproduced in accordance with the copyright policy of the publisher. Please refer to the journal's website for access to the definitive, published version.
Subject
Immunology not elsewhere classified
Biological Sciences
Agricultural and Veterinary Sciences
Medical and Health Sciences