dc.contributor.author | Lin, L | |
dc.contributor.author | Wu, XD | |
dc.contributor.author | Davey, AK | |
dc.contributor.author | Wang, J | |
dc.date.accessioned | 2017-05-03T16:01:13Z | |
dc.date.available | 2017-05-03T16:01:13Z | |
dc.date.issued | 2010 | |
dc.date.modified | 2011-02-11T08:03:08Z | |
dc.identifier.issn | 0951-418X | |
dc.identifier.doi | 10.1002/ptr.3003 | |
dc.identifier.uri | http://hdl.handle.net/10072/36091 | |
dc.description.abstract | The aim of present study was to investigate the effect of baicalin on hypoxia/reoxygenation (H/R) injury in cardiomyocytes and the mechanisms involved, particularly in relation to cytokines. The cardiomyocytes for the H/R groups were placed into a hypoxic chamber for 12 h and then underwent reoxygenation for 1 h. The cells in the TNF- groups were administered 100 ng/mL rrTNF- and incubated for 13 h under normal conditions. The cells in the baicalin pretreatment groups were administered 10 μM baicalin 30 min prior to exposure to H/R or TNF-. It was observed that pretreatment with baicalin (10 μM) significantly reduced the cell damage and death induced by H/R or TNF-. In the culture medium of the H/R cells, the SOD activity increased, while TNF- was decreased by baicalin. The levels of IL-6 in culture medium for H/R or TNF- treated cells were suppressed by baicalin pretreatment. In contrast, the levels of IL-10 in culture medium for H/R or TNF- treated cells were significantly elevated by baicalin. Moreover, baicalin inhibited the nuclear translocation of NF-κB induced by H/R or TNF-α. In conclusion, baicalin may protect cardiomyocytes from H/R injury through an anti-inflammatory mechanism. | |
dc.description.peerreviewed | Yes | |
dc.description.publicationstatus | Yes | |
dc.language | English | |
dc.language.iso | eng | |
dc.publisher | John Wiley and Sons Ltd | |
dc.publisher.place | United Kingdom | |
dc.relation.ispartofstudentpublication | N | |
dc.relation.ispartofpagefrom | 429 | |
dc.relation.ispartofpageto | 437 | |
dc.relation.ispartofissue | 3 | |
dc.relation.ispartofjournal | Phytotherapy Research | |
dc.relation.ispartofvolume | 24 | |
dc.rights.retention | Y | |
dc.subject.fieldofresearch | Chemical sciences | |
dc.subject.fieldofresearch | Biological sciences | |
dc.subject.fieldofresearch | Biomedical and clinical sciences | |
dc.subject.fieldofresearch | Pharmacology and pharmaceutical sciences not elsewhere classified | |
dc.subject.fieldofresearchcode | 34 | |
dc.subject.fieldofresearchcode | 31 | |
dc.subject.fieldofresearchcode | 32 | |
dc.subject.fieldofresearchcode | 321499 | |
dc.title | The anti-inflammatory effect of baicalin on hypoxia/reoxygenation and TNF-α induced injury in cultural rat cardiomyocytes | |
dc.type | Journal article | |
dc.type.description | C1 - Articles | |
dc.type.code | C - Journal Articles | |
gro.date.issued | 2010 | |
gro.hasfulltext | No Full Text | |
gro.griffith.author | Davey, Andrew | |