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dc.contributor.authorLin, L
dc.contributor.authorWu, XD
dc.contributor.authorDavey, AK
dc.contributor.authorWang, J
dc.date.accessioned2017-05-03T16:01:13Z
dc.date.available2017-05-03T16:01:13Z
dc.date.issued2010
dc.date.modified2011-02-11T08:03:08Z
dc.identifier.issn0951-418X
dc.identifier.doi10.1002/ptr.3003
dc.identifier.urihttp://hdl.handle.net/10072/36091
dc.description.abstractThe aim of present study was to investigate the effect of baicalin on hypoxia/reoxygenation (H/R) injury in cardiomyocytes and the mechanisms involved, particularly in relation to cytokines. The cardiomyocytes for the H/R groups were placed into a hypoxic chamber for 12 h and then underwent reoxygenation for 1 h. The cells in the TNF- groups were administered 100 ng/mL rrTNF- and incubated for 13 h under normal conditions. The cells in the baicalin pretreatment groups were administered 10 μM baicalin 30 min prior to exposure to H/R or TNF-. It was observed that pretreatment with baicalin (10 μM) significantly reduced the cell damage and death induced by H/R or TNF-. In the culture medium of the H/R cells, the SOD activity increased, while TNF- was decreased by baicalin. The levels of IL-6 in culture medium for H/R or TNF- treated cells were suppressed by baicalin pretreatment. In contrast, the levels of IL-10 in culture medium for H/R or TNF- treated cells were significantly elevated by baicalin. Moreover, baicalin inhibited the nuclear translocation of NF-κB induced by H/R or TNF-α. In conclusion, baicalin may protect cardiomyocytes from H/R injury through an anti-inflammatory mechanism.
dc.description.peerreviewedYes
dc.description.publicationstatusYes
dc.languageEnglish
dc.language.isoeng
dc.publisherJohn Wiley and Sons Ltd
dc.publisher.placeUnited Kingdom
dc.relation.ispartofstudentpublicationN
dc.relation.ispartofpagefrom429
dc.relation.ispartofpageto437
dc.relation.ispartofissue3
dc.relation.ispartofjournalPhytotherapy Research
dc.relation.ispartofvolume24
dc.rights.retentionY
dc.subject.fieldofresearchChemical sciences
dc.subject.fieldofresearchBiological sciences
dc.subject.fieldofresearchBiomedical and clinical sciences
dc.subject.fieldofresearchPharmacology and pharmaceutical sciences not elsewhere classified
dc.subject.fieldofresearchcode34
dc.subject.fieldofresearchcode31
dc.subject.fieldofresearchcode32
dc.subject.fieldofresearchcode321499
dc.titleThe anti-inflammatory effect of baicalin on hypoxia/reoxygenation and TNF-α induced injury in cultural rat cardiomyocytes
dc.typeJournal article
dc.type.descriptionC1 - Articles
dc.type.codeC - Journal Articles
gro.date.issued2010
gro.hasfulltextNo Full Text
gro.griffith.authorDavey, Andrew


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