Monodispersed submicron porous silica particles functionalized with CD derivatives for chiral CEC

Abstract

Rapid and efficient enantioseparation of halogen aryl alcohols and ߭blockers propranolol and pindolol in packed bed CEC (p-CEC) using as-prepared submicron porous silica chiral stationary phases (CSPs) has been achieved. Monodispersed 0.66 and 0.81?孠chiral submicron porous silica spheres were prepared using tetramethoxysilane and hexadecyltrimethylammonium bromide, followed by a hydrothermal treatment method with ammonia-ethanol to expand the pore of silica spheres without changing their spherical morphology. A proper specific surface of ca. 230?m2/g and pore sizes average of 6-8?nm were obtained by this method. The submicron porous silica spheres were modified with mono-6-phenylcarbamoylated ߭CD via thiol-en radical addition. They were packed into 9?cm 50?孿id capillary columns with photopolymerized monolithic frits. These submicron CSPs showed greater column efficiency (about 476 ?000 plates/m for 4-iodophenyl-1-ethanol) and higher resolution than the corresponding 3?孠CSP.