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dc.contributor.authorXiao, Yin
dc.contributor.authorWang, Yong
dc.contributor.authorOng, Teng-Teng
dc.contributor.authorGe, Liya
dc.contributor.authorTan, Swee Ngin
dc.contributor.authorYoung, David J
dc.contributor.authorTan, TTY
dc.contributor.authorNg, Siu-Choon
dc.date.accessioned2017-05-03T11:41:18Z
dc.date.available2017-05-03T11:41:18Z
dc.date.issued2010
dc.date.modified2011-02-14T09:14:03Z
dc.identifier.issn1615-9306
dc.identifier.doi10.1002/jssc.200900732
dc.identifier.urihttp://hdl.handle.net/10072/36163
dc.description.abstractNew single-isomer, cationic ߭cyclodextrins, including mono-6-deoxy-6-pyrrolidine-߭cyclodextrin chloride (pyCDCl), mono-6-deoxy-6-(N-methyl-pyrrolidine)-߭cyclodextrin chloride (N-CH3-pyCDCl), mono-6-deoxy-6-(N-(2-hydroxyethyl)-pyrrolidine)-߭cyclodextrin chloride (N-EtOH-pyCDCl), mono-6-deoxy-6-(2-hydroxymethyl-pyrrolidine)-߭cyclodextrin chloride (2-MeOH-pyCDCl) were synthesized and used as chiral selectors in capillary electrophoresis for the enantioseparation of carboxylic and hydroxycarboxylic acids and dansyl amino acids. The unsubstituted pyCDCl exhibited the greatest resolving ability. Most analytes were resolved over a wide range of pH from 6.0 to 9.0 with this chiral selector. In general, increasing pH led to a decrease in resolution. The effective mobilities of all the analytes were found to decrease with increasing CD concentration. The optimal concentration for most carboxylic acids and dansyl amino acid was in the range 5-7.5?mM and >15?mM for hydroxycarboxylic acids. 1H NMR experiments provided direct evidence of inclusion in the CD cavity.
dc.description.peerreviewedYes
dc.description.publicationstatusYes
dc.languageEnglish
dc.language.isoeng
dc.publisherWiley - VCH Verlag GmbHWiley
dc.publisher.placeGermany
dc.relation.ispartofstudentpublicationN
dc.relation.ispartofpagefrom1797
dc.relation.ispartofpageto1805
dc.relation.ispartofissue12
dc.relation.ispartofjournalJournal of Separation Science
dc.relation.ispartofvolume33
dc.rights.retentionY
dc.subject.fieldofresearchAnalytical chemistry
dc.subject.fieldofresearchSeparation science
dc.subject.fieldofresearchOther chemical sciences
dc.subject.fieldofresearchBiochemistry and cell biology
dc.subject.fieldofresearchcode3401
dc.subject.fieldofresearchcode340109
dc.subject.fieldofresearchcode3499
dc.subject.fieldofresearchcode3101
dc.titleChiral capillary electrophoresis with cationic pyrrolidinium-β-cyclodextrin derivatives as chiral selectors
dc.typeJournal article
dc.type.descriptionC1 - Articles
dc.type.codeC - Journal Articles
gro.date.issued2010
gro.hasfulltextNo Full Text
gro.griffith.authorYoung, David


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