Show simple item record

dc.contributor.authorWang, Yong
dc.contributor.authorYoung, David J
dc.contributor.authorTan, Timothy Thatt Yang
dc.contributor.authorNg, Siu-Choon
dc.date.accessioned2017-05-03T11:41:19Z
dc.date.available2017-05-03T11:41:19Z
dc.date.issued2010
dc.date.modified2011-02-14T09:14:05Z
dc.identifier.issn0021-9673
dc.identifier.doi10.1016/j.chroma.2010.06.003
dc.identifier.urihttp://hdl.handle.net/10072/36164
dc.description.abstractTwo cyclodextrin-based chiral stationary phases have been prepared by immobilization of functionalized mono-6-azido- -CD derivatives to alkynyl modified silica via "click" chemistry and applied to the HPLC enantioseparation of various chiral compounds. The perphenylcarbamatedCDCSP (CCP-CSP) exhibited excellent chiral recognition of a wide range of analytes including racemic aryl alcohols, flavonoids, bendroflumethiazide, atropine and some -blockers. Methanol proved to be a better organic modifier than acetonitrile for most of the analytes with the exception of bendroflumethiazide. The "click" chemistry immobilized permethylated CD CSP (CCM-CSP) afforded poor chiral recognition for most analytes, but could resolve non-aromatic ionone derivatives which were not separated on CCP-CSP. These results suggest that resolution with cyclodextrin derived CSPs depend on a complex interplay of 'host'-'guest' inclusion, hydrogen bonding, - and hydrophobic interactions.
dc.description.peerreviewedYes
dc.description.publicationstatusYes
dc.languageEnglish
dc.language.isoen_AU
dc.publisherElsevier
dc.publisher.placeNetherlands
dc.relation.ispartofstudentpublicationN
dc.relation.ispartofpagefrom5103
dc.relation.ispartofpageto5108
dc.relation.ispartofissue31
dc.relation.ispartofjournalJournal of Chromatography A
dc.relation.ispartofvolume1217
dc.rights.retentionY
dc.subject.fieldofresearchSeparation Science
dc.subject.fieldofresearchChemical Sciences
dc.subject.fieldofresearchEngineering
dc.subject.fieldofresearchTechnology
dc.subject.fieldofresearchcode030108
dc.subject.fieldofresearchcode03
dc.subject.fieldofresearchcode09
dc.subject.fieldofresearchcode10
dc.title"Click" immobilized perphenylcarbamated and permethylated cyclodextrin stationary phases for chiral high-performance liquid chromatography application
dc.typeJournal article
dc.type.descriptionC1 - Articles
dc.type.codeC - Journal Articles
gro.date.issued2010
gro.hasfulltextNo Full Text
gro.griffith.authorYoung, David


Files in this item

FilesSizeFormatView

There are no files associated with this item.

This item appears in the following Collection(s)

  • Journal articles
    Contains articles published by Griffith authors in scholarly journals.

Show simple item record