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dc.contributor.authorBoriachek, Kseniia
dc.contributor.authorIslam, Md Nazmul
dc.contributor.authorMoller, Andreas
dc.contributor.authorSalomon, Carlos
dc.contributor.authorNam-Trung, Nguyen
dc.contributor.authorHossain, Md Shahriar A
dc.contributor.authorYamauchi, Yusuke
dc.contributor.authorShiddiky, Muhammad JA
dc.date.accessioned2019-07-04T12:32:55Z
dc.date.available2019-07-04T12:32:55Z
dc.date.issued2018
dc.identifier.issn1613-6810
dc.identifier.doi10.1002/smll.201702153
dc.identifier.urihttp://hdl.handle.net/10072/364237
dc.description.abstractExosomes are nanoscale (≈30–150 nm) extracellular vesicles of endocytic origin that are shed by most types of cells and circulate in bodily fluids. Exosomes carry a specific composition of proteins, lipids, RNA, and DNA and can work as cargo to transfer this information to recipient cells. Recent studies on exosomes have shown that they play an important role in various biological processes, such as intercellular signaling, coagulation, inflammation, and cellular homeostasis. These functional roles are attributed to their ability to transfer RNA, proteins, enzymes, and lipids, thereby affecting the physiological and pathological conditions in various diseases, including cancer and neurodegenerative, infectious, and autoimmune diseases (e.g., cancer initiation, progression, and metastasis). Due to these unique characteristics, exosomes are considered promising biomarkers for the diagnosis and prognosis of various diseases via noninvasive or minimally invasive procedures. Over the last decade, a plethora of methodologies have been developed for analyzing disease-specific exosomes using optical and nonoptical tools. Here, the major biological functions, significance, and potential role of exosomes as biomarkers and therapeutics are discussed. Furthermore, an overview of the most commonly used techniques for exosome analysis, highlighting the major technical challenges and limitations of existing techniques, is presented.
dc.description.peerreviewedYes
dc.languageEnglish
dc.language.isoeng
dc.publisherJohn Wiley & Sons
dc.publisher.placeGermany
dc.relation.ispartofchapter1702153
dc.relation.ispartofpagefrom1
dc.relation.ispartofpageto21
dc.relation.ispartofissue6
dc.relation.ispartofjournalSmall
dc.relation.ispartofvolume14
dc.subject.fieldofresearchAnalytical chemistry not elsewhere classified
dc.subject.fieldofresearchcode340199
dc.titleBiological Functions and Current Advances in Isolation and Detection Strategies for Exosome Nanovesicles
dc.typeJournal article
dc.type.descriptionC1 - Articles
dc.type.codeC - Journal Articles
gro.facultyGriffith Sciences, School of Natural Sciences
gro.description.notepublicThis publication has been entered into Griffith Research Online as an Advanced Online Version.
gro.hasfulltextNo Full Text
gro.griffith.authorNguyen, Nam-Trung
gro.griffith.authorShiddiky, Muhammad J.


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