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dc.contributor.authorJimenez, Rocio
dc.contributor.authorIkonomopoulou, Maria P
dc.contributor.authorLopez, J Alejandro
dc.contributor.authorMiles, John J
dc.date.accessioned2019-07-04T12:32:56Z
dc.date.available2019-07-04T12:32:56Z
dc.date.issued2018
dc.identifier.issn0041-0101
dc.identifier.doi10.1016/j.toxicon.2017.11.006
dc.identifier.urihttp://hdl.handle.net/10072/364239
dc.description.abstractThis review catalogues recent advances in knowledge on venoms as standalone therapeutic agents or as blueprints for drug design, with an emphasis on venom-derived compounds that affects the immune system. We discuss venoms and venom-derived compounds that affect total immune cell numbers, immune cell proliferation, immune cell migration, immune cell phenotype and cytokine secretion. Identifying novel compounds that ‘tune’ the system, up-regulating the immune response during infectious disease and cancer and down-regulating the immune response during autoimmunity, will greatly expand the tool kit of human immunotherapeutics. Targeting these pathways may also open therapeutic options that alleviate symptoms of envenomation. Finally, combining recent advances in venomics with progress in low cost, high-throughput screening platforms will no doubt yield hundreds of prototype immune modulating compounds in the coming years.
dc.description.peerreviewedYes
dc.languageEnglish
dc.language.isoeng
dc.publisherElsevier
dc.publisher.placeUnited Kingdom
dc.relation.ispartofpagefrom18
dc.relation.ispartofpageto24
dc.relation.ispartofjournalToxicon
dc.relation.ispartofvolume141
dc.subject.fieldofresearchPharmacology and Pharmaceutical Sciences not elsewhere classified
dc.subject.fieldofresearchPharmacology and Pharmaceutical Sciences
dc.subject.fieldofresearchcode111599
dc.subject.fieldofresearchcode1115
dc.titleImmune drug discovery from venoms
dc.typeJournal article
dc.type.descriptionC1 - Articles
dc.type.codeC - Journal Articles
dcterms.licensehttp://creativecommons.org/licenses/by-nc-nd/4.0/
dc.description.versionVersion of Record (VoR)
gro.facultyGriffith Sciences, School of Natural Sciences
gro.rights.copyright© 2018 Elsevier. Licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International Licence (http://creativecommons.org/licenses/by-nc-nd/4.0/) which permits unrestricted, non-commercial use, distribution and reproduction in any medium, providing that the work is properly cited.
gro.hasfulltextFull Text
gro.griffith.authorLopez Ramirez, Alejandro
gro.griffith.authorMiles, John J.
gro.griffith.authorJimenez Martinez, Rocio


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