dc.contributor.author | Jimenez, Rocio | |
dc.contributor.author | Ikonomopoulou, Maria P | |
dc.contributor.author | Lopez, J Alejandro | |
dc.contributor.author | Miles, John J | |
dc.date.accessioned | 2019-07-04T12:32:56Z | |
dc.date.available | 2019-07-04T12:32:56Z | |
dc.date.issued | 2018 | |
dc.identifier.issn | 0041-0101 | |
dc.identifier.doi | 10.1016/j.toxicon.2017.11.006 | |
dc.identifier.uri | http://hdl.handle.net/10072/364239 | |
dc.description.abstract | This review catalogues recent advances in knowledge on venoms as standalone therapeutic agents or as blueprints for drug design, with an emphasis on venom-derived compounds that affects the immune system. We discuss venoms and venom-derived compounds that affect total immune cell numbers, immune cell proliferation, immune cell migration, immune cell phenotype and cytokine secretion. Identifying novel compounds that ‘tune’ the system, up-regulating the immune response during infectious disease and cancer and down-regulating the immune response during autoimmunity, will greatly expand the tool kit of human immunotherapeutics. Targeting these pathways may also open therapeutic options that alleviate symptoms of envenomation. Finally, combining recent advances in venomics with progress in low cost, high-throughput screening platforms will no doubt yield hundreds of prototype immune modulating compounds in the coming years. | |
dc.description.peerreviewed | Yes | |
dc.language | English | |
dc.language.iso | eng | |
dc.publisher | Elsevier | |
dc.publisher.place | United Kingdom | |
dc.relation.ispartofpagefrom | 18 | |
dc.relation.ispartofpageto | 24 | |
dc.relation.ispartofjournal | Toxicon | |
dc.relation.ispartofvolume | 141 | |
dc.subject.fieldofresearch | Pharmacology and pharmaceutical sciences | |
dc.subject.fieldofresearch | Pharmacology and pharmaceutical sciences not elsewhere classified | |
dc.subject.fieldofresearchcode | 3214 | |
dc.subject.fieldofresearchcode | 321499 | |
dc.title | Immune drug discovery from venoms | |
dc.type | Journal article | |
dc.type.description | C1 - Articles | |
dc.type.code | C - Journal Articles | |
dcterms.license | http://creativecommons.org/licenses/by-nc-nd/4.0/ | |
dc.description.version | Version of Record (VoR) | |
gro.faculty | Griffith Sciences, School of Natural Sciences | |
gro.rights.copyright | © 2018 Elsevier. Licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International Licence (http://creativecommons.org/licenses/by-nc-nd/4.0/) which permits unrestricted, non-commercial use, distribution and reproduction in any medium, providing that the work is properly cited. | |
gro.hasfulltext | Full Text | |
gro.griffith.author | Lopez Ramirez, Alejandro | |