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  • Defining ‘healthy’ in preschool-aged children for forced oscillation technique reference equations

    Author(s)
    Shackleton, Claire
    Czovek, Dorottya
    Grimwood, Keith
    Ware, Robert S
    Radics, Bence
    Hantos, Zoltan
    Sly, Peter D
    Griffith University Author(s)
    Grimwood, Keith
    Ware, Robert
    Year published
    2018
    Metadata
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    Abstract
    Background and objective Selecting ‘healthy’ preschool-aged children for reference ranges may not be straightforward. Relaxing inclusion criteria for normative data does not affect spirometry z-scores. We therefore investigated the effect of similarly relaxing inclusion criteria in preschoolers on reference ranges for respiratory impedance (Zrs) using a modified forced oscillation technique (FOT). Methods The International Study of Asthma and Allergies in Childhood questionnaire classified 585 children into a healthy and five mutually exclusive groups. Zrs was measured between 4 and 26 Hz and resistance (R) and compliance ...
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    Background and objective Selecting ‘healthy’ preschool-aged children for reference ranges may not be straightforward. Relaxing inclusion criteria for normative data does not affect spirometry z-scores. We therefore investigated the effect of similarly relaxing inclusion criteria in preschoolers on reference ranges for respiratory impedance (Zrs) using a modified forced oscillation technique (FOT). Methods The International Study of Asthma and Allergies in Childhood questionnaire classified 585 children into a healthy and five mutually exclusive groups. Zrs was measured between 4 and 26 Hz and resistance (R) and compliance (C) obtained by model fitting. Prediction models were determined using mixed effect models and z-scores compared between healthy children and the five groups. Results Zrs data were obtained for 494 participants (4.30 ± 0.7 years) on 587 occasions. Comparison of the Zrs z-scores between the healthy children and the health groups found significant differences in children with asthma, current wheeze and respiratory symptoms, but not in children born preterm or with early-life wheeze. Adding these two groups to the healthy dataset had no significant effect on the distribution of z-scores and increased the size of the dataset by 22.3%. Conclusion Our data suggest that preschool-aged children born preterm or with early-life wheeze can be included in FOT reference equations, while those with asthma, current wheeze and respiratory symptoms within 4 weeks of testing should be excluded. This more inclusive approach results in more robust FOT reference ranges.
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    Journal Title
    Respirology
    DOI
    https://doi.org/10.1111/resp.13186
    Note
    This publication has been entered into Griffith Research Online as an Advanced Online Version.
    Subject
    Medical and Health Sciences not elsewhere classified
    Medical and Health Sciences
    Publication URI
    http://hdl.handle.net/10072/364252
    Collection
    • Journal articles

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