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dc.contributor.authorJ. Frohmader, Terenceen_US
dc.contributor.authorChaboyer, Wendyen_US
dc.contributor.authorK. Robertson, Iainen_US
dc.contributor.authorGowardman, Johnen_US
dc.contributor.editorCindy L. Munro, Richard H. Saveen_US
dc.description.abstractBackground Diarrhea has adverse consequences for critically ill patients, health care staff, and health care costs. Objective To evaluate the efficacy of the multispecies probiotic VSL#3 in reducing the mean number of episodes of liquid stool in enterally fed critically ill patients. Methods A single-center, double-blind, randomized, placebo-controlled pilot study was done in a 6-bed intensive care unit in a 330-bed public hospital in Australia. A total of 45 adults (20 intervention, 25 control) who required enteral nutrition for more than 72 hours were given VSL#3 or a placebo twice daily. The frequency (mean number of episodes per patient per day) and weight (grams per day) were determined for both liquid stool and liquid and loose (unformed) stool. Results The 2 groups of patients had no demographic or clinical differences. Patients received enteral nutrition for a mean of 8.5 days (SD, 5.4) and were studied for a mean of 11.9 days (SD, 5.6). Compared with the control group, the intervention group had a significant reduction in the frequency of liquid stools (incidence rate ratio, 0.50; 95% confidence interval, 0.27 to 0.93; P = .03). Smaller but still significant differences also occurred between the groups in both the frequency of episodes and the weight of liquid and loose (unformed) stool. Conclusion VSL#3 was effective in reducing the frequency of liquid stool in critically ill patients receiving enteral nutrition. Probiotics possibly can minimize diarrhea in critically ill tube-fed patients, but more controlled clinical trials are needed.en_US
dc.publisherAmerican Association of Critical-Care Nursesen_US
dc.publisher.placeUnited Statesen_US
dc.relation.ispartofjournalAmerican Journal of Critical Careen_US
dc.subject.fieldofresearchNursing not elsewhere classifieden_US
dc.titleDecrease in Frequency of Liquid Stool in Enterally Fed Critically Ill Patients Given the Multispecies Probiotic VSL#3: A Pilot Trialen_US
dc.typeJournal articleen_US
dc.type.descriptionC1 - Peer Reviewed (HERDC)en_US
dc.type.codeC - Journal Articlesen_US
gro.rights.copyrightSelf-archiving of the author-manuscript version is not yet supported by this journal. Please refer to the journal link for access to the definitive, published version or contact the author[s] for more information.en_AU
gro.hasfulltextNo Full Text

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