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  • Characterisation of Campylobacter jejuni Genes Involved in Aerobic Respiration

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    Calderon-Gomez_2012_02Thesis.pdf (6.189Mb)
    Author(s)
    Calderon-Gomez, Lirio I.
    Primary Supervisor
    Korolik, Victoria
    Other Supervisors
    Wilson, Jennifer
    Mendz, George
    Year published
    2012
    Metadata
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    Abstract
    Campylobacter jejuni is an important pathogen that causes human bacterial gastroenteritis worldwide and can colonise the intestinal mucosa of all food-producing animals. Under such conditions C. jejuni is able to tolerate a variety of stresses, which they must in order to permit their transmission to a suitable environment for growth. C. jejuni is an obligate microaerophile, with the ability to survive in oxygen conditions and the natural environment indicating a potential to carry out aerobic respiration. This, in principle, allows growth in the absence and presence of oxygen. Despite its importance, effective control of ...
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    Campylobacter jejuni is an important pathogen that causes human bacterial gastroenteritis worldwide and can colonise the intestinal mucosa of all food-producing animals. Under such conditions C. jejuni is able to tolerate a variety of stresses, which they must in order to permit their transmission to a suitable environment for growth. C. jejuni is an obligate microaerophile, with the ability to survive in oxygen conditions and the natural environment indicating a potential to carry out aerobic respiration. This, in principle, allows growth in the absence and presence of oxygen. Despite its importance, effective control of Campylobacter spp. in the food chain and the design of disease prevention strategies are restricted by a poor understanding of the genetics, physiology and virulence of this organism. Therefore, to gain a greater understanding of its survival in different environments, it is important to understand how the respiratory pathway functions in C. jejuni in order to gain a greater understanding of its physiology. C. jejuni encodes a large respiratory enzyme complex, named NDH-I or complex I, which is composed of 14 different genes designated as the nuo operon. These genes are clustered in a conserved order in bacteria like Escherichia coli and Paracoccus denitrificans, however in C. jejuni the subunits nuoE and nuoF have been replaced by two subunits of unknown function, designated NuoX and NuoY (encoded by cj1575c and cj1574c genes respectively).
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    Thesis Type
    Thesis (PhD Doctorate)
    Degree Program
    Doctor of Philosophy (PhD)
    School
    Institute for Glycomics
    DOI
    https://doi.org/10.25904/1912/867
    Copyright Statement
    The author owns the copyright in this thesis, unless stated otherwise.
    Item Access Status
    Public
    Subject
    Campylobacter jejuni
    C. jejuni
    Microaerophile
    Aerobic respiration
    Gastroenteritis
    Publication URI
    http://hdl.handle.net/10072/365229
    Collection
    • Theses - Higher Degree by Research

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