• myGriffith
    • Staff portal
    • Contact Us⌄
      • Future student enquiries 1800 677 728
      • Current student enquiries 1800 154 055
      • International enquiries +61 7 3735 6425
      • General enquiries 07 3735 7111
      • Online enquiries
      • Staff phonebook
    View Item 
    •   Home
    • Griffith Theses
    • Theses - Higher Degree by Research
    • View Item
    • Home
    • Griffith Theses
    • Theses - Higher Degree by Research
    • View Item
    JavaScript is disabled for your browser. Some features of this site may not work without it.

    Browse

  • All of Griffith Research Online
    • Communities & Collections
    • Authors
    • By Issue Date
    • Titles
  • This Collection
    • Authors
    • By Issue Date
    • Titles
  • Statistics

  • Most Popular Items
  • Statistics by Country
  • Most Popular Authors
  • Support

  • Contact us
  • FAQs
  • Admin login

  • Login
  • Development of a Passive Control System for Ventricular Assist Devices

    Thumbnail
    View/Open
    Pauls, Jo_Final thesis_Redacted.pdf (4.385Mb)
    Author(s)
    Pauls, Jo P.
    Primary Supervisor
    Tansley, Geoffrey
    Other Supervisors
    Hall, Wayne
    Fraser, John
    Gregory, Shaun
    Year published
    2017
    Metadata
    Show full item record
    Abstract
    Cardiovascular diseases are a leading cause of death throughout the developed world. With the demand for donor hearts far exceeding the supply, a bridge-to-transplant or permanent solution is required. This can be achieved with rotary ventricular assist devices (VADs). Rotary VADs show a weaker response to preload than the native heart. This may lead to ventricular suction or pulmonary congestion, which can be deleterious to the patient’s recovery. A physiological control system which optimizes responsiveness of VADs may reduce adverse events. Active physiological control systems rely either on pressure and flow measurements ...
    View more >
    Cardiovascular diseases are a leading cause of death throughout the developed world. With the demand for donor hearts far exceeding the supply, a bridge-to-transplant or permanent solution is required. This can be achieved with rotary ventricular assist devices (VADs). Rotary VADs show a weaker response to preload than the native heart. This may lead to ventricular suction or pulmonary congestion, which can be deleterious to the patient’s recovery. A physiological control system which optimizes responsiveness of VADs may reduce adverse events. Active physiological control systems rely either on pressure and flow measurements or on estimated data. However these controllers may be limited by the low reliability of long term blood pressure and flow sensors or potential of inaccurate estimators due to changes in the VAD circuit (e.g. thrombus formation resulting in false estimation). A passive physiological control system might be able to overcome the limitation of active physiological control systems. This research project had three key aims: • Investigation of the steady state and time response of the healthy heart and circulatory system to changes in patient state (e.g. active postural changes and exercise). • In-vitro development and in-vivo validation of novel compliant inflow cannulae for rotary LVADs and RVADs to improve preload sensitivity of RBPs and provide a passive physiological control system for ventricular suction prevention. • Rigorous in-vitro evaluation of the compliant inflow cannulae together with various active physiological control systems previously presented in the literature under identical conditions.
    View less >
    Thesis Type
    Thesis (PhD Doctorate)
    Degree Program
    Doctor of Philosophy (PhD)
    School
    Griffith School of Engineering
    DOI
    https://doi.org/10.25904/1912/2586
    Copyright Statement
    The author owns the copyright in this thesis, unless stated otherwise.
    Subject
    Cardiovascular diseases
    Rotary ventricular assist devices (VADs)
    Donor hearts
    Pulmonary congestion
    Ventricular suction
    Publication URI
    http://hdl.handle.net/10072/365268
    Collection
    • Theses - Higher Degree by Research

    Footer

    Disclaimer

    • Privacy policy
    • Copyright matters
    • CRICOS Provider - 00233E

    Tagline

    • Gold Coast
    • Logan
    • Brisbane - Queensland, Australia
    First Peoples of Australia
    • Aboriginal
    • Torres Strait Islander