Investigation of glycosyltransferases of Moraxella catarrhalis and Moraxella bovis

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Author(s)
Primary Supervisor
Peak, Ian
Wilson, Jenny
Other Supervisors
Tiralongo, Joe
Year published
2011
Metadata
Show full item recordAbstract
Glycosyltransferases are a diverse group of enzymes found in natire and perform critical functions in all domains of life by transferring sugars to various targets, forming glycoside bonds. In Gram-negative bacteria such as Moraxella catarrhalis, glycosyltransferases are essential in the biosynthesis of the lipooligosaccharide (LOS) structure, a major component of the outer membrane. M. catarrhalis is a frequent coloniser of the human upper respiratory tract and is associated with ear infections and diseases of the lower respiratory tract, particularly in patients with underlying lung impairment. M. catarrhalis strains omly ...
View more >Glycosyltransferases are a diverse group of enzymes found in natire and perform critical functions in all domains of life by transferring sugars to various targets, forming glycoside bonds. In Gram-negative bacteria such as Moraxella catarrhalis, glycosyltransferases are essential in the biosynthesis of the lipooligosaccharide (LOS) structure, a major component of the outer membrane. M. catarrhalis is a frequent coloniser of the human upper respiratory tract and is associated with ear infections and diseases of the lower respiratory tract, particularly in patients with underlying lung impairment. M. catarrhalis strains omly display three major LOS serotypes: A, B and C. The genetic basis of M. catarrhalis LOS biosynthesis has been elucidated and functions suggested for each of the identified LOS glycosyltransferases.
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View more >Glycosyltransferases are a diverse group of enzymes found in natire and perform critical functions in all domains of life by transferring sugars to various targets, forming glycoside bonds. In Gram-negative bacteria such as Moraxella catarrhalis, glycosyltransferases are essential in the biosynthesis of the lipooligosaccharide (LOS) structure, a major component of the outer membrane. M. catarrhalis is a frequent coloniser of the human upper respiratory tract and is associated with ear infections and diseases of the lower respiratory tract, particularly in patients with underlying lung impairment. M. catarrhalis strains omly display three major LOS serotypes: A, B and C. The genetic basis of M. catarrhalis LOS biosynthesis has been elucidated and functions suggested for each of the identified LOS glycosyltransferases.
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Thesis Type
Thesis (PhD Doctorate)
Degree Program
Doctor of Philosophy (PhD)
School
Institute for Glycomics
Copyright Statement
The author owns the copyright in this thesis, unless stated otherwise.
Item Access Status
Public
Note
This thesis has been scanned. Figure 1.1 pge 3 has been removed. The journal article has not been published here.
Subject
Glycosyltransferases
Moraxella catarrhalis
lipooligosaccharide
Moraxella bovis