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  • An Investigation of Gene Variants in Adenosine Receptors and Changes with Essential Hypertension

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    Ho_2012_02Thesis.pdf (2.199Mb)
    Author(s)
    Ho, Ming-Fen
    Primary Supervisor
    Rose'meyer, Roselyn
    Other Supervisors
    Lewohl, Joanne
    Year published
    2012
    Metadata
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    Abstract
    Alternative splicing is increasingly emerging as a key mechanism that contributes to the transcript and protein complexity observed in human and other species. Alternative splicing frequently occurs in human genes, approximately 70% and generates different protein isoforms in specific tissue types and pathological conditions. A splice variant can form a new isoform of the protein to modify the function. However, it is also possible that the transcripts lack coding capacity and fail to be involved in regulatory activities. Essential hypertension is the most common cardiovascular disease, the prevalence of which is approximately ...
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    Alternative splicing is increasingly emerging as a key mechanism that contributes to the transcript and protein complexity observed in human and other species. Alternative splicing frequently occurs in human genes, approximately 70% and generates different protein isoforms in specific tissue types and pathological conditions. A splice variant can form a new isoform of the protein to modify the function. However, it is also possible that the transcripts lack coding capacity and fail to be involved in regulatory activities. Essential hypertension is the most common cardiovascular disease, the prevalence of which is approximately 26% worldwide. Additionally, essential hypertension is considered to be a multifactoral disorder and its aetiology has yet to be clearly identified. It is known whether adenosine receptor subtypes mediating vasodilator responses in vascular tissue vary according to the blood vessel location. However, it is unknown that adenosine receptor splice variants are expressed in cardiovascular tissues and whether the gene expression patterns have a role in the development of hypertension.
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    Thesis Type
    Thesis (PhD Doctorate)
    Degree Program
    Doctor of Philosophy (PhD)
    School
    School of Medicine
    DOI
    https://doi.org/10.25904/1912/3378
    Copyright Statement
    The author owns the copyright in this thesis, unless stated otherwise.
    Item Access Status
    Public
    Subject
    Hypertension
    Cardiovascular disease
    Gene expression
    Adenosine receptors
    Publication URI
    http://hdl.handle.net/10072/365325
    Collection
    • Theses - Higher Degree by Research

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