An Investigation of Gene Variants in Adenosine Receptors and Changes with Essential Hypertension

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Author(s)
Primary Supervisor
Rose'meyer, Roselyn
Other Supervisors
Lewohl, Joanne
Year published
2012
Metadata
Show full item recordAbstract
Alternative splicing is increasingly emerging as a key mechanism that contributes to the transcript and protein complexity observed in human and other species. Alternative splicing frequently occurs in human genes, approximately 70% and generates different protein isoforms in specific tissue types and pathological conditions. A splice variant can form a new isoform of the protein to modify the function. However, it is also possible that the transcripts lack coding capacity and fail to be involved in regulatory activities. Essential hypertension is the most common cardiovascular disease, the prevalence of which is approximately ...
View more >Alternative splicing is increasingly emerging as a key mechanism that contributes to the transcript and protein complexity observed in human and other species. Alternative splicing frequently occurs in human genes, approximately 70% and generates different protein isoforms in specific tissue types and pathological conditions. A splice variant can form a new isoform of the protein to modify the function. However, it is also possible that the transcripts lack coding capacity and fail to be involved in regulatory activities. Essential hypertension is the most common cardiovascular disease, the prevalence of which is approximately 26% worldwide. Additionally, essential hypertension is considered to be a multifactoral disorder and its aetiology has yet to be clearly identified. It is known whether adenosine receptor subtypes mediating vasodilator responses in vascular tissue vary according to the blood vessel location. However, it is unknown that adenosine receptor splice variants are expressed in cardiovascular tissues and whether the gene expression patterns have a role in the development of hypertension.
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View more >Alternative splicing is increasingly emerging as a key mechanism that contributes to the transcript and protein complexity observed in human and other species. Alternative splicing frequently occurs in human genes, approximately 70% and generates different protein isoforms in specific tissue types and pathological conditions. A splice variant can form a new isoform of the protein to modify the function. However, it is also possible that the transcripts lack coding capacity and fail to be involved in regulatory activities. Essential hypertension is the most common cardiovascular disease, the prevalence of which is approximately 26% worldwide. Additionally, essential hypertension is considered to be a multifactoral disorder and its aetiology has yet to be clearly identified. It is known whether adenosine receptor subtypes mediating vasodilator responses in vascular tissue vary according to the blood vessel location. However, it is unknown that adenosine receptor splice variants are expressed in cardiovascular tissues and whether the gene expression patterns have a role in the development of hypertension.
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Thesis Type
Thesis (PhD Doctorate)
Degree Program
Doctor of Philosophy (PhD)
School
School of Medicine
Copyright Statement
The author owns the copyright in this thesis, unless stated otherwise.
Item Access Status
Public
Subject
Hypertension
Cardiovascular disease
Gene expression
Adenosine receptors