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  • Targeting Bone Marrow Small Non-coding RNAs in Cancer

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    Plummer_2013_02Thesis.pdf (6.008Mb)
    Author(s)
    Plummer, Prue N.
    Primary Supervisor
    Mellick, Albert
    Other Supervisors
    Griffiths, Lyn
    Forwood, Mark
    McMillan, Nigel
    Year published
    2013
    Metadata
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    Abstract
    Cancer is one of the leading causes of death worldwide. Despite extensive research cancer is predicated to be the leading cause of death by 2020. One element of cancer development, which has been successfully targeted clinically resulting in impaired tumour growth and spread (metastases), is the process by which tumours enroll vasculature. This is referred to as tumour angiogenesis. However, the problems currently associated with current anti-angiogenic therapies (eg. Avastin) is that they are prone to adaptive resistance (the process of initial response, followed by hypoxia and rapid relapse). Furthermore, such therapies ...
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    Cancer is one of the leading causes of death worldwide. Despite extensive research cancer is predicated to be the leading cause of death by 2020. One element of cancer development, which has been successfully targeted clinically resulting in impaired tumour growth and spread (metastases), is the process by which tumours enroll vasculature. This is referred to as tumour angiogenesis. However, the problems currently associated with current anti-angiogenic therapies (eg. Avastin) is that they are prone to adaptive resistance (the process of initial response, followed by hypoxia and rapid relapse). Furthermore, such therapies target normal aspects of human biology, including the immune system, wound healing and vascular homeostasis. This leads to unintended and adverse side-affects. Bone marrow (BM) derived Endothelial Progenitor Cells (EPCs) play a critical role in tumour angiogenesis and adaptive resistance. Therefore, targeting these cells offers a novel anti-angiogenic therapy, which may not be associated with the problems of current treatments.
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    Thesis Type
    Thesis (PhD Doctorate)
    Degree Program
    Doctor of Philosophy (PhD)
    School
    School of Medical Science
    DOI
    https://doi.org/10.25904/1912/858
    Copyright Statement
    The author owns the copyright in this thesis, unless stated otherwise.
    Item Access Status
    Public
    Subject
    Tumour angiogenesis
    Endothelial progenitor cells (EPCs)
    Cancer research
    Bone marrow small non-coding RNAs
    Ribonucleic acid
    Publication URI
    http://hdl.handle.net/10072/365333
    Collection
    • Theses - Higher Degree by Research

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