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  • Northern New South Wales Marine Invertebrate-Derived Natural Products; A Source of Bioactive S. aureus Drug-like Molecules

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    Hayton_2017_01Thesis.pdf (9.078Mb)
    Author(s)
    Hayton, Joshua B.
    Primary Supervisor
    Carroll, Anthony
    Other Supervisors
    Grant, Gary
    Year published
    2017
    Metadata
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    Abstract
    This thesis describes the development of a rapid antistaphylococcal bioassay and chemical investigation of antistaphylococcal extracts derived from marine invertebrates collected from northern New South Wales. This thesis is divided into three sections. Chapter 2 describes the development of a novel HTS antistaphylococcal bioassay and the subsequent screening of a marine invertebrate extract collection using the developed assay. Chapters 3-7 report on the isolation and structure elucidation of natural products from antistaphylococcal extracts derived from three sponges and two bryozoans. Finally, in chapter 8, the isolated ...
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    This thesis describes the development of a rapid antistaphylococcal bioassay and chemical investigation of antistaphylococcal extracts derived from marine invertebrates collected from northern New South Wales. This thesis is divided into three sections. Chapter 2 describes the development of a novel HTS antistaphylococcal bioassay and the subsequent screening of a marine invertebrate extract collection using the developed assay. Chapters 3-7 report on the isolation and structure elucidation of natural products from antistaphylococcal extracts derived from three sponges and two bryozoans. Finally, in chapter 8, the isolated natural products were investigated to determine if they were active against Staphylococcus aureus. The MIC80 of active compounds were reported as was the bacteriostatic or bactericidal mode of action of these bioactive compounds.
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    Thesis Type
    Thesis (PhD Doctorate)
    Degree Program
    Doctor of Philosophy (PhD)
    School
    Griffith School of Environment
    DOI
    https://doi.org/10.25904/1912/2388
    Copyright Statement
    The author owns the copyright in this thesis, unless stated otherwise.
    Subject
    Antistaphylococcal bioassay
    Novel HTS antistaphylococcal bioassay
    Marine invertebrates
    Staphylococcus aureus
    Natural products
    Publication URI
    http://hdl.handle.net/10072/365380
    Collection
    • Theses - Higher Degree by Research

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