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dc.contributor.advisorRipper, Justin
dc.contributor.authorLindahl, Karl-Fredrik
dc.date.accessioned2018-01-23T02:18:15Z
dc.date.available2018-01-23T02:18:15Z
dc.date.issued2014
dc.identifier.doi10.25904/1912/536
dc.identifier.urihttp://hdl.handle.net/10072/365418
dc.description.abstractFuro- and pyranoquinolinone containing natural products have been isolated from the Rutaceae family sine the 1960’s1 and 1970’s2 and have shown to exhibit a range of biological activities such as antifungal, antibacterial, antiviral, antimicrobial, antimalarial, insecticidal, antineoplastic, antidiuretic, antiarrythmic and sedative properties. Due to this, synthetic strategies have been developed to afford some of the selected natural products. In the course of extracting natural products at Natural Product Discovery (Brisbane, QLD, Australia), one natural product, 1.01, was isolated from the species Euodia asteridala (Rutaceae) and was of interest because of the ongoing screening of that class of molecules and the synthetic challanges involved. The natural product 1.01 consists of a furoquinolinone core with a cyclopropane ring fused onto the C2-C3 carbons of the furan ring, and a gem dimethyl functionality off the quarternary carbon of the cyclopropane ring. This thesis explores a total synthesis approach to compound 1.01, with focus on a new synthetic strategy to afford the furoquinolinone core structure as a key intermediate.
dc.languageEnglish
dc.publisherGriffith University
dc.publisher.placeBrisbane
dc.rights.copyrightThe author owns the copyright in this thesis, unless stated otherwise.
dc.subject.keywordsFuroquinolinone
dc.subject.keywordsRutaceae Family
dc.subject.keywordsAntifungal
dc.subject.keywordsAntiviral
dc.subject.keywordsAntibacteria
dc.subject.keywordsAntiarrythmic
dc.subject.keywordsAntimalarial
dc.titleA Total Synthesis Approach Towards a Novel Furoquinolinone Natural Product Isolated from the Rutaceae Family
dc.typeGriffith thesis
gro.facultyScience, Environment, Engineering and Technology
gro.description.notepublicThis thesis has been scanned.
gro.rights.copyrightThe author owns the copyright in this thesis, unless stated otherwise.
gro.hasfulltextFull Text
dc.contributor.otheradvisorQuinn, Ron
dc.contributor.otheradvisorCarroll, Anthony
dc.rights.accessRightsPublic
gro.identifier.gurtIDgu1325655187687
gro.source.ADTshelfnoADT0
gro.source.GURTshelfnoGURT1106
gro.thesis.degreelevelThesis (PhD Doctorate)
gro.thesis.degreeprogramDoctor of Philosophy (PhD)
gro.departmentSchool of Biomolecular and Physical Sciences
gro.griffith.authorLindahl, Fredrik


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