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  • Breast Cancer Stem Cells: Tumourspheres and Implications for Therapy

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    Morrison_2011_02Thesis.pdf (6.418Mb)
    Author(s)
    Morrison, Brian
    Primary Supervisor
    Lopez, Alejandro
    Other Supervisors
    Kennedy, Derek
    Year published
    2011
    Metadata
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    Abstract
    Breast cancer is a heterogenous disease, composed of tumour cells with differing gene expressions and phenotypes. Tumour heterogeneity has several important consequences for breast cancer including: (i) making classification by morphological and expression analysis more difficult because of the diversity within single tumours with the consequence that the majority of cells of the tumour will dominate this classification whether or not these cells are critical for diagnosis or treatment; (ii) treatments may fail to eradicate tumours simply by failing to eliminate one of the cell subtypes within the tumour; and (iii) differing ...
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    Breast cancer is a heterogenous disease, composed of tumour cells with differing gene expressions and phenotypes. Tumour heterogeneity has several important consequences for breast cancer including: (i) making classification by morphological and expression analysis more difficult because of the diversity within single tumours with the consequence that the majority of cells of the tumour will dominate this classification whether or not these cells are critical for diagnosis or treatment; (ii) treatments may fail to eradicate tumours simply by failing to eliminate one of the cell subtypes within the tumour; and (iii) differing abilities of the cell subtypes for dissemination and metastasis. Recently, a rare subpopulation of cells within tumours has been described with the ability to initiate and sustain tumour growth, to resist traditional therapies and to allow for secondary tumour dissemination. These cells are termed tumour-initiating cells or cancer stem cells, or alternatively, in the case of breast cancer, breast cancer stem cells. The therapeutic targeting of these cells has the potential to eliminate residual disease and may become an important component of a multi-modality treatment of cancer. Presented here is an investigation into: (i) ways to functionally and phenotypically identify breast cancer stem cells; (ii) the role of breast cancer stem cells in disease from both clinical samples and using xenograft assays; and (iii) the potential to target these cells.
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    Thesis Type
    Thesis (PhD Doctorate)
    Degree Program
    Doctor of Philosophy (PhD)
    School
    School of Biomolecular and Physical Sciences
    DOI
    https://doi.org/10.25904/1912/1434
    Copyright Statement
    The author owns the copyright in this thesis, unless stated otherwise.
    Item Access Status
    Public
    Subject
    Breast cancer
    Tumour heterogeneity
    Stem cells
    Publication URI
    http://hdl.handle.net/10072/365433
    Collection
    • Theses - Higher Degree by Research

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