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  • Investigating the Potential of Primary Sulfonamides as Antimalarial Drug Leads

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    Fisher_2015_02Thesis.pdf (3.136Mb)
    Author(s)
    Fisher, Gill M.
    Primary Supervisor
    Andrews, Kathy
    Poulsen, Sally-Ann
    Other Supervisors
    Boyle, Glen
    Year published
    2015
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    Abstract
    Malaria remains one of the world’s most important infectious diseases causing over 600,000 deaths annually, mainly in African children under the age of five [1]. In the absence of a licenced vaccine, malaria prevention and treatment relies on drugs and vector control [1]. Unfortunately malaria parasite resistance has emerged to currently used antimalarial drugs, including the current gold standard artemisinin combination therapies (ACTs) [1-3]. Added to this, the majority of agents in the current antimalarial drug discovery and development portfolio are based on known antimalarial pharmacophores [4], which may compromise ...
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    Malaria remains one of the world’s most important infectious diseases causing over 600,000 deaths annually, mainly in African children under the age of five [1]. In the absence of a licenced vaccine, malaria prevention and treatment relies on drugs and vector control [1]. Unfortunately malaria parasite resistance has emerged to currently used antimalarial drugs, including the current gold standard artemisinin combination therapies (ACTs) [1-3]. Added to this, the majority of agents in the current antimalarial drug discovery and development portfolio are based on known antimalarial pharmacophores [4], which may compromise their widespread use due to potential issues of cross resistance. With only one new antimalarial chemical class (chemotype) presently under development, the spiroindolones [5], there is an urgent need to ensure that the antimalarial drug discovery pipeline is primed with new chemotypes, ideally with novel modes of action in order to combat resistance. In this thesis project this problem was addressed by investigating the antimalarial potential of primary sulfonamides (PS), a chemotype not currently used for malaria, but with a proven track record for treatment of other diseases, including glaucoma, renal disorders and epilepsy [6].
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    Thesis Type
    Thesis (PhD Doctorate)
    Degree Program
    Doctor of Philosophy (PhD)
    School
    School of Natural Sciences
    DOI
    https://doi.org/10.25904/1912/3440
    Copyright Statement
    The author owns the copyright in this thesis, unless stated otherwise.
    Item Access Status
    Public
    Subject
    Antimalarial drugs
    Malaria
    Infectious diseases
    Publication URI
    http://hdl.handle.net/10072/365454
    Collection
    • Theses - Higher Degree by Research

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