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  • Plasmodium falciparum Plasmepsins IX and X: Structure- Function Analysis and the Discovery of New Lead Antimalarial drugs

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    McGeorge_2014_02Thesis.pdf (3.799Mb)
    Author(s)
    McGeorge, Rachael Dawn
    Primary Supervisor
    Skinner-Adams, Tina
    Brown, Chris
    Other Supervisors
    Gardiner, Donald
    Year published
    2014
    Metadata
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    Abstract
    Malaria is a deadly parasitic infection that poses an enormous threat to global health. While drugs are available, all of our current antimalarials are being gradually rendered ineffective by spreading drug resistance. Reports of increasing tolerance to artemisinin combination therapies, our most potent antimalarial treatments, are particularly concerning. To combat this problem there is an urgent need to identify new and unique targets within the malaria parasite against which novel chemotherapeutics can be developed. Studies investigating the antimalarial activity of HIV protease inhibitors (HIV PIs) have shown that these ...
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    Malaria is a deadly parasitic infection that poses an enormous threat to global health. While drugs are available, all of our current antimalarials are being gradually rendered ineffective by spreading drug resistance. Reports of increasing tolerance to artemisinin combination therapies, our most potent antimalarial treatments, are particularly concerning. To combat this problem there is an urgent need to identify new and unique targets within the malaria parasite against which novel chemotherapeutics can be developed. Studies investigating the antimalarial activity of HIV protease inhibitors (HIV PIs) have shown that these drugs can inhibit the growth of Plasmodium in vitro, in vivo and ex vivo at clinically relevant concentrations. While the anti-parasitic action of these drugs is not fully understood, it is believed these agents inhibit the growth of parasites by targeting an essential malarial aspartic protease or plasmepsin (PM) and that these enzymes may represent new targets for drug development. The aim of this thesis was to investigate the Plasmodium falciparum aspartic proteases PM IX and X as potential new targets for antimalarial development.
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    Thesis Type
    Thesis (PhD Doctorate)
    Degree Program
    Doctor of Philosophy (PhD)
    School
    School of Biomolecular and Physical Sciences
    DOI
    https://doi.org/10.25904/1912/610
    Copyright Statement
    The author owns the copyright in this thesis, unless stated otherwise.
    Item Access Status
    Public
    Subject
    Malaria
    Anti-malarial drugs
    Plasmodium falciparum Plasmepsins IX and X
    Publication URI
    http://hdl.handle.net/10072/365553
    Collection
    • Theses - Higher Degree by Research

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