An Examination of intermittent Hypoxia Exposure on Key Haematological and Immune-Stress Responses in Normally Active Humans
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Altitude is one naturally occurring source of low oxygen levels (hypoxia) and altitude acclimatization has been utilized to trigger cellular protection in elite athlete training. Acclimatization to low oxygen (pre-conditioning) confers cross protection to other physical, environmental and pharmacological stressors, and using animal models this phenomenon has been translated for use in the clinical setting, for example in ischemic preconditioning used immediately prior to brain and cardiac surgery. An alternative to altitude acclimatization is passive intermittent hypoxia exposure (IHE), a laboratory-based technique developed to simulate the effects of altitude acclimatization. In healthy individuals IHE has been reported to stimulate adaptations produced in the body in response to altitude. These adaptations include increases in hypoxia inducible factor, erythropoietin, red blood cell count, hematocrit, haemoglobin concentration and reticulocyte production. Such increases offer a protective role by enhancing oxygen delivery to the tissues and by increasing cellular protection and tolerance to further hypoxic insults.
Thesis (PhD Doctorate)
Doctor of Philosophy (PhD)
School of Physiotherapy and Exercise Science
Item Access Status
Intermittent hypoxia exposure