An Examination of intermittent Hypoxia Exposure on Key Haematological and Immune-Stress Responses in Normally Active Humans
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Author(s)
Primary Supervisor
Renshaw, Gillian
Other Supervisors
Adams, Lewis
Year published
2013
Metadata
Show full item recordAbstract
Altitude is one naturally occurring source of low oxygen levels (hypoxia) and altitude acclimatization has been utilized to trigger cellular protection in elite athlete training. Acclimatization to low oxygen (pre-conditioning) confers cross protection to other physical, environmental and pharmacological stressors, and using animal models this phenomenon has been translated for use in the clinical setting, for example in ischemic preconditioning used immediately prior to brain and cardiac surgery. An alternative to altitude acclimatization is passive intermittent hypoxia exposure (IHE), a laboratory-based technique developed ...
View more >Altitude is one naturally occurring source of low oxygen levels (hypoxia) and altitude acclimatization has been utilized to trigger cellular protection in elite athlete training. Acclimatization to low oxygen (pre-conditioning) confers cross protection to other physical, environmental and pharmacological stressors, and using animal models this phenomenon has been translated for use in the clinical setting, for example in ischemic preconditioning used immediately prior to brain and cardiac surgery. An alternative to altitude acclimatization is passive intermittent hypoxia exposure (IHE), a laboratory-based technique developed to simulate the effects of altitude acclimatization. In healthy individuals IHE has been reported to stimulate adaptations produced in the body in response to altitude. These adaptations include increases in hypoxia inducible factor, erythropoietin, red blood cell count, hematocrit, haemoglobin concentration and reticulocyte production. Such increases offer a protective role by enhancing oxygen delivery to the tissues and by increasing cellular protection and tolerance to further hypoxic insults.
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View more >Altitude is one naturally occurring source of low oxygen levels (hypoxia) and altitude acclimatization has been utilized to trigger cellular protection in elite athlete training. Acclimatization to low oxygen (pre-conditioning) confers cross protection to other physical, environmental and pharmacological stressors, and using animal models this phenomenon has been translated for use in the clinical setting, for example in ischemic preconditioning used immediately prior to brain and cardiac surgery. An alternative to altitude acclimatization is passive intermittent hypoxia exposure (IHE), a laboratory-based technique developed to simulate the effects of altitude acclimatization. In healthy individuals IHE has been reported to stimulate adaptations produced in the body in response to altitude. These adaptations include increases in hypoxia inducible factor, erythropoietin, red blood cell count, hematocrit, haemoglobin concentration and reticulocyte production. Such increases offer a protective role by enhancing oxygen delivery to the tissues and by increasing cellular protection and tolerance to further hypoxic insults.
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Thesis Type
Thesis (PhD Doctorate)
Degree Program
Doctor of Philosophy (PhD)
School
School of Physiotherapy and Exercise Science
Copyright Statement
The author owns the copyright in this thesis, unless stated otherwise.
Item Access Status
Public
Subject
Hypoxia
Altitude acclimatization
Intermittent hypoxia exposure