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dc.contributor.advisorRenshaw, Gillian
dc.contributor.authorTobin, Barbaraen_US
dc.date.accessioned2018-01-23T02:20:44Z
dc.date.available2018-01-23T02:20:44Z
dc.date.issued2013en_US
dc.identifier.doi10.25904/1912/3586
dc.identifier.urihttp://hdl.handle.net/10072/365637
dc.description.abstractAltitude is one naturally occurring source of low oxygen levels (hypoxia) and altitude acclimatization has been utilized to trigger cellular protection in elite athlete training. Acclimatization to low oxygen (pre-conditioning) confers cross protection to other physical, environmental and pharmacological stressors, and using animal models this phenomenon has been translated for use in the clinical setting, for example in ischemic preconditioning used immediately prior to brain and cardiac surgery. An alternative to altitude acclimatization is passive intermittent hypoxia exposure (IHE), a laboratory-based technique developed to simulate the effects of altitude acclimatization. In healthy individuals IHE has been reported to stimulate adaptations produced in the body in response to altitude. These adaptations include increases in hypoxia inducible factor, erythropoietin, red blood cell count, hematocrit, haemoglobin concentration and reticulocyte production. Such increases offer a protective role by enhancing oxygen delivery to the tissues and by increasing cellular protection and tolerance to further hypoxic insults.en_US
dc.languageEnglishen_US
dc.publisherGriffith Universityen_US
dc.publisher.placeBrisbaneen_US
dc.rights.copyrightThe author owns the copyright in this thesis, unless stated otherwise.en_US
dc.subject.keywordsHypoxiaen_US
dc.subject.keywordsAltitude acclimatizationen_US
dc.subject.keywordsIntermittent hypoxia exposureen_US
dc.titleAn Examination of intermittent Hypoxia Exposure on Key Haematological and Immune-Stress Responses in Normally Active Humansen_US
dc.typeGriffith thesisen_US
gro.facultyGriffith Healthen_US
gro.rights.copyrightThe author owns the copyright in this thesis, unless stated otherwise.
gro.hasfulltextFull Text
dc.contributor.otheradvisorAdams, Lewis
dc.rights.accessRightsPublicen_US
gro.identifier.gurtIDgu1380086083570en_US
gro.source.ADTshelfnoADT0en_US
gro.source.GURTshelfnoGURTen_US
gro.thesis.degreelevelThesis (PhD Doctorate)en_US
gro.thesis.degreeprogramDoctor of Philosophy (PhD)en_US
gro.departmentSchool of Physiotherapy and Exercise Scienceen_US
gro.griffith.authorTobin, Barbara M.


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