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  • An Investigation into the Synthesis of 5,7-diamino-3,5,7,9-tetradeoxy-nonulosonic acid analogues

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    Zunk_2014_01Abstract.pdf (163.4Kb)
    Zunk_2014_02Thesis.pdf (11.12Mb)
    Author(s)
    Zunk, Matthew S.
    Primary Supervisor
    Kiefel, Milton
    Other Supervisors
    Wilson, Jennifer
    Year published
    9
    Metadata
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    Abstract
    This thesis describes the results of a research program aimed at investigating synthetic methodology towards obtaining novel 5,7-diamino-3,5,7,9-tetradeoxy-nonulosonic acid analogues. Syntheses outlined in this thesis comprise varied approaches which include a chemoenzymatic approach and two chemical approaches from differing starting materials. Pseudaminic acid and legionaminic acid are 5,7-diamino-3,5,7,9-tetradeoxy-nonulosonic acids that play an essential role in the pathogenic capabilities of numerous clinically relevant Gram-negative bacteria. Over the past twenty-five years several structural and functional group ...
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    This thesis describes the results of a research program aimed at investigating synthetic methodology towards obtaining novel 5,7-diamino-3,5,7,9-tetradeoxy-nonulosonic acid analogues. Syntheses outlined in this thesis comprise varied approaches which include a chemoenzymatic approach and two chemical approaches from differing starting materials. Pseudaminic acid and legionaminic acid are 5,7-diamino-3,5,7,9-tetradeoxy-nonulosonic acids that play an essential role in the pathogenic capabilities of numerous clinically relevant Gram-negative bacteria. Over the past twenty-five years several structural and functional group derivatives of these carbohydrates have been isolated from many bacterial species, highlighting the fact that these compounds are widespread throughout nature. However, to date their exact biological significance is yet to be clearly determined and the limited syntheses described within the literature are for the parent compounds only, not structural analogues. Therefore, the primary aim of this research program was to fill a void in the literature in regard to creating a versatile and efficient synthesis of pseudaminic acid and legionaminic acid analogues.
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    Thesis Type
    Thesis (PhD Doctorate)
    Degree Program
    Doctor of Philosophy (PhD)
    School
    Institute for Glycomics
    DOI
    https://doi.org/10.25904/1912/3258
    Copyright Statement
    The author owns the copyright in this thesis, unless stated otherwise.
    Item Access Status
    Public
    Subject
    Carboxylic acids.
    Publication URI
    http://hdl.handle.net/10072/365643
    Collection
    • Theses - Higher Degree by Research

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