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dc.contributor.advisorHeadrick, John
dc.contributor.authorWee, Shirley Sheau Yanen_US
dc.date.accessioned2018-01-23T02:21:45Z
dc.date.available2018-01-23T02:21:45Z
dc.date.issued2012en_US
dc.identifier.doi10.25904/1912/354
dc.identifier.urihttp://hdl.handle.net/10072/365704
dc.description.abstractThe P2 purinoceptor family are perhaps the earliest (or most 'primitive') group of regulatory cell surface receptors, and have been studied intensely for several decades. The P2 receptors are subdivided into two major families, P2X subtypes (P2X1, P2X2, P2X3, P2X4, P2X5, P2X6 and P2X7,) and P2Y subtypes (P2Y1, P2Y2, P2Y4, P2Y6, P2Y11, P2Y12, P2Y13, and P2Y14). In the cardiovascular system P2 purinoceptors have been implicated both in vasoconstriction and vasodilatation, cardiac inotropy, cardioprotection (including pre- and postconditioning responses), and diseasedependent cardiac dysfunction. Furthermore, increasing evidence indicates that P2 purinoceptors form functional heteromeric assemblies under certain conditions, adding to the complexity of purinoceptor functionality. Thus, full characterisation of the regulatory function of these receptors is yet to be accomplished. This thesis comprises a series of studies aimed at elucidating the roles of P2 purinoceptors (primarily the P2Y2 subtype) in protecting the heart during ischaemia-reperfusion (relevant to the injurious effects of acute myocardial infarction).en_US
dc.languageEnglishen_US
dc.publisherGriffith Universityen_US
dc.publisher.placeBrisbaneen_US
dc.rights.copyrightThe author owns the copyright in this thesis, unless stated otherwise.en_US
dc.subject.keywordsP2 Purinoceptor familyen_US
dc.subject.keywordsRegulatory cell surface receptorsen_US
dc.subject.keywordsIschaemic injuryen_US
dc.subject.keywordsIschaemic-reperfusionen_US
dc.subject.keywordsMyocardial resistance to ischaemiaen_US
dc.subject.keywordsMyocardial resistance to reperfusionen_US
dc.titleP2Purinoceptor-Dependent Cardioprotection in Ischaemic-Reperfused Myocardiumen_US
dc.typeGriffith thesisen_US
gro.facultyScience, Environment, Engineering and Technologyen_US
gro.rights.copyrightThe author owns the copyright in this thesis, unless stated otherwise.
gro.hasfulltextFull Text
dc.contributor.otheradvisorPeart, Jason
dc.rights.accessRightsPublicen_US
gro.identifier.gurtIDgu1357522143975en_US
gro.source.ADTshelfnoADT0en_US
gro.source.GURTshelfnoGURT1356en_US
gro.thesis.degreelevelThesis (PhD Doctorate)en_US
gro.thesis.degreeprogramDoctor of Philosophy (PhD)en_US
gro.departmentSchool of Medical Scienceen_US
gro.griffith.authorWee, Shirley S.


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