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dc.contributor.advisorWei, Ming
dc.contributor.authorQi, Ji
dc.date.accessioned2018-01-23T02:21:55Z
dc.date.available2018-01-23T02:21:55Z
dc.date.issued2016
dc.identifier.doi10.25904/1912/3403
dc.identifier.urihttp://hdl.handle.net/10072/365729
dc.description.abstractThe skin of the toads is known to be rich in bufadienolide compounds (a group of cardiac glycosides) that exhibit antitumor activity. For example, Huachansu (Cinobufacini), the aqueous extracts from the dried toad skin of Bufo bufo gargarizans Cantor or Bufo melanostictus Schneider, has been widely used in clinical therapy for various cancers in China. Clinical data have indicated that Cinobufacini may have significant anticancer activity with low toxicity and few side effects. Data to date suggest that treatment with Cinobufacini may also enhance the quality of life for patients with cancer. Huachansu contains several groups of compounds including peptides, bufadienolides/cardiac glycosides, cholesterols, indole alkaloids, bufogargarizanines, organic acid, and others. Bufadienolides, such as bufalin, cinobufagin, resibufogenin, and telocinobufagin, are responsible for the anti-cancer properties of Huachansu through disruption of the cell cycle and consequent inhibition of cell proliferation, induction of apoptosis, suppression of the NF-B pathway, immunomodulation and reversal of multi-drug resistance. The Australian cane toad (Bufo marinus) is also known as a source of bufadienolides, therefore is also considered as a new source of candidate lead compounds for drug development. Previous studies have shown that cane toad skin aqueous extracts (CTSAE) exhibited a stronger cardiac glycosides-like activity than the extracts of other organic solvents and have a suppression effect on Na+, K+‐ATPase in experimental models. However, no assay was performed to clarify the chemical constituents and pharmaceutical effects of CTSAE on cancer cells in previous studies.
dc.languageEnglish
dc.publisherGriffith University
dc.publisher.placeBrisbane
dc.rights.copyrightThe author owns the copyright in this thesis, unless stated otherwise.
dc.subject.keywordsBufadienolide compounds
dc.subject.keywordsCane toad skin
dc.subject.keywordsAnti-cancer agents
dc.subject.keywordsBufo bufo gargarizans Cantor
dc.subject.keywordsBufo melanostictus Schneider
dc.subject.keywordsAnti-inflammatory agents
dc.titleCane Toad Skin Extracts as Anti-Inflammatory and Anti-Cancer Agents
dc.typeGriffith thesis
gro.facultyGriffith Health
gro.rights.copyrightThe author owns the copyright in this thesis, unless stated otherwise.
gro.hasfulltextFull Text
dc.contributor.otheradvisorHashimi, Saeed
dc.contributor.otheradvisorMunn, Alan
dc.contributor.otheradvisorVider, Jelena
dc.rights.accessRightsPublic
gro.identifier.gurtIDgu1485234512544
gro.thesis.degreelevelThesis (PhD Doctorate)
gro.thesis.degreeprogramDoctor of Philosophy (PhD)
gro.departmentSchool of Medical Science
gro.griffith.authorQi, Ji


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