dc.contributor.advisor | Wei, Ming | |
dc.contributor.author | Qi, Ji | |
dc.date.accessioned | 2018-01-23T02:21:55Z | |
dc.date.available | 2018-01-23T02:21:55Z | |
dc.date.issued | 2016 | |
dc.identifier.doi | 10.25904/1912/3403 | |
dc.identifier.uri | http://hdl.handle.net/10072/365729 | |
dc.description.abstract | The skin of the toads is known to be rich in bufadienolide compounds (a group of cardiac glycosides) that exhibit antitumor activity. For example, Huachansu (Cinobufacini), the aqueous extracts from the dried toad skin of Bufo bufo gargarizans Cantor or Bufo melanostictus Schneider, has been widely used in clinical therapy for various cancers in China. Clinical data have indicated that Cinobufacini may have significant anticancer activity with low toxicity and few side effects. Data to date suggest that treatment with Cinobufacini may also enhance the quality of life for patients with cancer. Huachansu contains several groups of compounds including peptides, bufadienolides/cardiac glycosides, cholesterols, indole alkaloids, bufogargarizanines, organic acid, and others. Bufadienolides, such as bufalin, cinobufagin, resibufogenin, and telocinobufagin, are responsible for the anti-cancer properties of Huachansu through disruption of the cell cycle and consequent inhibition of cell proliferation, induction of apoptosis, suppression of the NF-B pathway, immunomodulation and reversal of multi-drug resistance. The Australian cane toad (Bufo marinus) is also known as a source of bufadienolides, therefore is also considered as a new source of candidate lead compounds for drug development. Previous studies have shown that cane toad skin aqueous extracts (CTSAE) exhibited a stronger cardiac glycosides-like activity than the extracts of other organic solvents and have a suppression effect on Na+, K+‐ATPase in experimental models. However, no assay was performed to clarify the chemical constituents and pharmaceutical effects of CTSAE on cancer cells in previous studies. | |
dc.language | English | |
dc.publisher | Griffith University | |
dc.publisher.place | Brisbane | |
dc.rights.copyright | The author owns the copyright in this thesis, unless stated otherwise. | |
dc.subject.keywords | Bufadienolide compounds | |
dc.subject.keywords | Cane toad skin | |
dc.subject.keywords | Anti-cancer agents | |
dc.subject.keywords | Bufo bufo gargarizans Cantor | |
dc.subject.keywords | Bufo melanostictus Schneider | |
dc.subject.keywords | Anti-inflammatory agents | |
dc.title | Cane Toad Skin Extracts as Anti-Inflammatory and Anti-Cancer Agents | |
dc.type | Griffith thesis | |
gro.faculty | Griffith Health | |
gro.rights.copyright | The author owns the copyright in this thesis, unless stated otherwise. | |
gro.hasfulltext | Full Text | |
dc.contributor.otheradvisor | Hashimi, Saeed | |
dc.contributor.otheradvisor | Munn, Alan | |
dc.contributor.otheradvisor | Vider, Jelena | |
dc.rights.accessRights | Public | |
gro.identifier.gurtID | gu1485234512544 | |
gro.thesis.degreelevel | Thesis (PhD Doctorate) | |
gro.thesis.degreeprogram | Doctor of Philosophy (PhD) | |
gro.department | School of Medical Science | |
gro.griffith.author | Qi, Ji | |