The Glycointeractome of Neisseria Meningitidis
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Author(s)
Primary Supervisor
Seib, Kate
Jennings, Michael
Other Supervisors
Hartley-Tassell, Lauren
Year published
2017
Metadata
Show full item recordAbstract
Neisseria meningitidis, an exclusive human pathogen, poses a considerable public health threat. Despite the availability of effective antibiotics, and vaccines for serogroups A, B, C, W and Y, N. meningitidis remains a leading cause of bacterial meningitis [1], with mortality rates as high as 10% (owing to the rapid onsets characteristic of the disease) and survivors often endure debilitating sequelae [2]. Furthermore, in light of the fact that changes in serogroup circulation is unpredictable, there remains a need for a broad
spectrum vaccine [3].
N. meningitidis expresses numerous adhesins that allow it to interact with ...
View more >Neisseria meningitidis, an exclusive human pathogen, poses a considerable public health threat. Despite the availability of effective antibiotics, and vaccines for serogroups A, B, C, W and Y, N. meningitidis remains a leading cause of bacterial meningitis [1], with mortality rates as high as 10% (owing to the rapid onsets characteristic of the disease) and survivors often endure debilitating sequelae [2]. Furthermore, in light of the fact that changes in serogroup circulation is unpredictable, there remains a need for a broad spectrum vaccine [3]. N. meningitidis expresses numerous adhesins that allow it to interact with diverse microenvironments within the host - from asymptomatic nasopharyngeal colonization of the mucosal epithelia, to invasion and spread within the blood stream and infection of the meninges. On the host side, the receptors involved in these stages of meningococcal infection are not fully elucidated, but are known to involve several carbohydrate structures (glycans). This thesis seeks to fully characterise glycan binding by N. meningitidis.
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View more >Neisseria meningitidis, an exclusive human pathogen, poses a considerable public health threat. Despite the availability of effective antibiotics, and vaccines for serogroups A, B, C, W and Y, N. meningitidis remains a leading cause of bacterial meningitis [1], with mortality rates as high as 10% (owing to the rapid onsets characteristic of the disease) and survivors often endure debilitating sequelae [2]. Furthermore, in light of the fact that changes in serogroup circulation is unpredictable, there remains a need for a broad spectrum vaccine [3]. N. meningitidis expresses numerous adhesins that allow it to interact with diverse microenvironments within the host - from asymptomatic nasopharyngeal colonization of the mucosal epithelia, to invasion and spread within the blood stream and infection of the meninges. On the host side, the receptors involved in these stages of meningococcal infection are not fully elucidated, but are known to involve several carbohydrate structures (glycans). This thesis seeks to fully characterise glycan binding by N. meningitidis.
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Thesis Type
Thesis (PhD Doctorate)
Degree Program
Doctor of Philosophy (PhD)
School
Institute for Glycomics
Copyright Statement
The author owns the copyright in this thesis, unless stated otherwise.
Subject
Neisseria meningitidis
Broad spectrum vaccine
Meningococcal infection
Glycan binding
Glycointeractome