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  • Modulation of leukocyte recruitment in animal models of inflammation in vivo

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    Culver_2009_02Thesis.pdf (37.84Mb)
    Author(s)
    Culver, Hannah
    Primary Supervisor
    O'Donnell, Stella
    Other Supervisors
    Griffiths, Lyn
    Year published
    2009
    Metadata
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    Abstract
    Inflammation is an important underlying cause of many chronic diseases, for example in allergic asthma. Glucocorticosteroids provide a powerful anti-inflammatory treatment but are associated with severe side effects when used at high doses for prolonged periods of time; new alternative or adjunct drugs therapies are therefore required. The recruitment of leukocytes to sites of inflammation represents both a key feature of the inflammatory response and a principal source of inflammatory mediators to perpetuate disease. Novel drugs which inhibit leukocyte recruitment or activation may offer a basis for new anti-inflammatory ...
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    Inflammation is an important underlying cause of many chronic diseases, for example in allergic asthma. Glucocorticosteroids provide a powerful anti-inflammatory treatment but are associated with severe side effects when used at high doses for prolonged periods of time; new alternative or adjunct drugs therapies are therefore required. The recruitment of leukocytes to sites of inflammation represents both a key feature of the inflammatory response and a principal source of inflammatory mediators to perpetuate disease. Novel drugs which inhibit leukocyte recruitment or activation may offer a basis for new anti-inflammatory treatments, while early evidence of pharmacological activity in vivo can help prioritise the selection and development of compounds. The present study employed, in controlled experiments, animal models to ascertain in vivo the action of several naturally occurring or synthetic compounds to modulate leukocyte recruitment and to measure any effect they may exert by counting the number of recruited leukocytes (neutrophils or eosinophils) in response to an inflammatory stimuli (used as an objective measure of drug action). Three series of experiments were conducted: one, in a mouse pouch model to test the reaction of differently pre-treated animals to cytokine stimulus; the second, in a guinea-pig model to assess the potentiating effect of pre-treatment to allergen challenge in sensitised animals; thirdly, in the same sensitised guinea-pig model to determine the anti-inflammatory action of a commercially available complementary therapy.
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    Thesis Type
    Thesis (PhD Doctorate)
    Degree Program
    Doctor of Philosophy (PhD)
    School
    School of Medical Science
    DOI
    https://doi.org/10.25904/1912/240
    Copyright Statement
    The author owns the copyright in this thesis, unless stated otherwise.
    Subject
    Inflammation
    Allergic asthma
    Leukocyte
    Glucocorticosteroids
    Publication URI
    http://hdl.handle.net/10072/365779
    Collection
    • Theses - Higher Degree by Research

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