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  • Chemical and Biological Investigations of Anticancer Compounds from Australian Ascidians

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    Da Silva Liberio_2014_02Thesis.pdf (9.577Mb)
    Author
    Da Silva Liberio, Michelle
    Primary Supervisor
    Ron Quinn
    Rohan Davis
    Other Supervisors
    Colleen Nelson
    Year published
    2014
    Metadata
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    Abstract
    Nature is the main source of anticancer agents with about 60% of the current anticancer drugs originating in some way from natural products. Many cytotoxic natural products have been isolated from marine invertebrates. One group of marine animals that have made significant contributions is the tunicates or ascidians. Ascidians belonging to the family Didemnidae are known to be a prolific and rich source of new chemical entities with biological activity. This study was divided into two main components. In the first part, Didemnid ascidians collected from the Great Barrier Reef (GBR) were investigated for their chemical diversity ...
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    Nature is the main source of anticancer agents with about 60% of the current anticancer drugs originating in some way from natural products. Many cytotoxic natural products have been isolated from marine invertebrates. One group of marine animals that have made significant contributions is the tunicates or ascidians. Ascidians belonging to the family Didemnidae are known to be a prolific and rich source of new chemical entities with biological activity. This study was divided into two main components. In the first part, Didemnid ascidians collected from the Great Barrier Reef (GBR) were investigated for their chemical diversity using spectroscopic and spectrometric techniques. In part two, an ascidian drug discovery screening library was generated and subsequently used to identify cytotoxic or cytostatic compounds in prostate (LNCaP) and breast (MDA-MB-231) cancer cells. The ascidian natural products isolated in part 1 were all tested in these cancer cell lines. Moreover, one of the cytotoxic compounds identified from the screening studies was subjected to mechanism of action studies.
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    Thesis Type
    Thesis (PhD Doctorate)
    Degree Program
    Doctor of Philosophy (PhD)
    School
    School of Biomolecular and Physical Sciences
    Item Access Status
    Public
    Subject
    Anticancer agents
    Ascidians
    Prostate (LNCaP) cancer cells
    Breast (MDA-MB-231) cancer cells
    Publication URI
    http://hdl.handle.net/10072/365813
    Collection
    • Theses - Higher Degree by Research

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