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dc.contributor.advisorWeible, Michael
dc.contributor.authorToppinen, Kelly Marie
dc.date.accessioned2018-01-23T02:23:01Z
dc.date.available2018-01-23T02:23:01Z
dc.date.issued2016
dc.identifier.doi10.25904/1912/577
dc.identifier.urihttp://hdl.handle.net/10072/365832
dc.description.abstractAdult neurogenesis in the subventricular zone (SVZ) is a highly dynamic and finely-tuned process, subject to modulation by various physiological stimuli. Fast- dividing transit-amplifying (type C) cells are the immediate progeny of adult neural stem cells in the SVZ. These type C cells play a key role in neurogenesis by expanding cell numbers that eventually give rise to neuroblasts destined for the olfactory bulbs (OB). The size of the progenitor pool, and ultimately the number of neurons that engage in synaptic competition at the OB, is largely determined by the balance between proliferation and differentiation of these cells. Identifying the signalling mechanisms that regulate type C cell fate is an essential step towards understanding how intermediate progenitor pools are maintained in the adult neurogenic niches. A key feature of type C cells is their transient expression and activation of epidermal growth factor receptor (EGFR), which is a critical signal involved in regulating their undifferentiated and proliferative state in vitro, and in maintaining the number of neurons produced in vivo. EGFR activation leads to multiple complex signal transduction pathways, including Ca2+ liberation from the endoplasmic reticulum (ER). Biological systems can transduce information by initiating and/or altering the spatial and temporal dynamics of Ca2+ within the cell, allowing for distinct biological signals to be transmitted in a process known as Ca2+-encoding. In this study, the role Ca2+-encoding plays in EGFR signal transduction was examined.
dc.languageEnglish
dc.publisherGriffith University
dc.publisher.placeBrisbane
dc.rights.copyrightThe author owns the copyright in this thesis, unless stated otherwise.
dc.subject.keywordsAdult neurogenesis in the subventricular zone
dc.subject.keywordsFast- dividing transit-amplifying (type C) cells
dc.subject.keywordsC-cells
dc.subject.keywordsEpidermal growth factor receptor
dc.titleEGFR Activates NFAT3 through Frequency Modulated Ca2+ Oscillations to Regulate the Proliferation of Transit-Amplifying (type C) Cells in the Adult SVZ
dc.typeGriffith thesis
gro.facultyScience, Environment, Engineering and Technology
gro.rights.copyrightThe author owns the copyright in this thesis, unless stated otherwise.
gro.hasfulltextFull Text
dc.contributor.otheradvisorMackay-Sim, Alan
dc.rights.accessRightsPublic
gro.identifier.gurtIDgu1490755104785
gro.thesis.degreelevelThesis (PhD Doctorate)
gro.thesis.degreeprogramDoctor of Philosophy (PhD)
gro.departmentSChool of Natural Sciences
gro.griffith.authorToppinen, Kelly M.


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