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  • An Examination into the Molecular Associations Between Cholesterol Homeostasis and the Neurodegenerative Disease Ataxia telangiectasia

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    Nourse_2008_02Thesis.pdf (6.886Mb)
    Author(s)
    Nourse, Jamie P.
    Primary Supervisor
    Watters, Dianne
    Other Supervisors
    Bushell, Gillian
    Year published
    2008
    Metadata
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    Abstract
    The Ataxia telangiectasia (A-T) syndrome is a multisystem disorder exhibiting a complex array of clinical features for which there is no effective therapy. The earliest and most debilitating aspect of this disease is progressive ataxia resulting from neurodegeneration of the cerebellum. Several lines of evidence suggest a potential function for ATM in the maintenance of cellular homeostasis, and disruptions in functional ATM appear to result in alterations cholesterol homeostasis. This association may provide some insight into the neurodegenerative aspect of this disease. Cholesterol homeostasis is particularly significant ...
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    The Ataxia telangiectasia (A-T) syndrome is a multisystem disorder exhibiting a complex array of clinical features for which there is no effective therapy. The earliest and most debilitating aspect of this disease is progressive ataxia resulting from neurodegeneration of the cerebellum. Several lines of evidence suggest a potential function for ATM in the maintenance of cellular homeostasis, and disruptions in functional ATM appear to result in alterations cholesterol homeostasis. This association may provide some insight into the neurodegenerative aspect of this disease. Cholesterol homeostasis is particularly significant in the central nervous system (CNS) with several neurodegenerative disorders involving disturbances in cholesterol homeostasis. The goal of this thesis was to attempt to establish a potential relationship between ATM and cholesterol homeostasis. As well it was hoped the establishment of a mechanism for such a relationship may help contribute to the establishment of therapies for this debilitating aspect of A-T...
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    Thesis Type
    Thesis (PhD Doctorate)
    Degree Program
    Doctor of Philosophy (PhD)
    School
    School of Biomolecular and Physical Sciences
    DOI
    https://doi.org/10.25904/1912/1484
    Copyright Statement
    The author owns the copyright in this thesis, unless stated otherwise.
    Item Access Status
    Public
    Subject
    cholesterol homeostasis
    neurodegenerative syndrome
    Ataxia telangiectasia
    neurodegenerative syndrome Ataxia telangiectasia
    A-T syndrome
    multisystem disorder
    neurodegeneration
    Publication URI
    http://hdl.handle.net/10072/365866
    Collection
    • Theses - Higher Degree by Research

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