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  • Formulation and Investigation of Specialised Dosage Forms for the Systematic Delivery of the Selective Antineoplastic a-Tocopheryl Succinate

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    Seshadri_2011_02Thesis.pdf (1.358Mb)
    Author(s)
    Seshadri, Madhumathi
    Primary Supervisor
    Grant, Gary
    Other Supervisors
    Chan, Yiu-Ngok
    Neuzil, Jiri
    Year published
    2011
    Metadata
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    Abstract
    Background. a-Tocopheryl succinate, a redox-silent analogue of vitamin E, has been shown to selectively induce apoptosis in a variety of cancers. However, a-tocopheryl succinate is rendered ineffective when administered orally due to hepatic metabolism. Transdermal delivery has been identified as an alternative approach for delivering in-tact a-tocopheryl succinate systemically. Aims and objectives. The aim of this study was to compound a liposomal formulation of a-tocopheryl succinate and evaluate the transdermal diffusion in an in-vitro Franz diffusion cell assay. The feasibility of transdermal delivery was further evaluated ...
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    Background. a-Tocopheryl succinate, a redox-silent analogue of vitamin E, has been shown to selectively induce apoptosis in a variety of cancers. However, a-tocopheryl succinate is rendered ineffective when administered orally due to hepatic metabolism. Transdermal delivery has been identified as an alternative approach for delivering in-tact a-tocopheryl succinate systemically. Aims and objectives. The aim of this study was to compound a liposomal formulation of a-tocopheryl succinate and evaluate the transdermal diffusion in an in-vitro Franz diffusion cell assay. The feasibility of transdermal delivery was further evaluated by studying the potential metabolism of a-tocopheryl succinate by esterases, which are commonly located in the skin. Methods. Large quantities of a-tocopheryl succinate was sourced and characterised by nuclear magnetic resonance, mass spectrometry, infrared spectroscopy and differential scanning calorimetry for the compounding of transdermal dosage forms. Analytical high performance liquid chromatography and extraction methods were developed and validated to isolate, identify and quantify a-tocopheryl succinate.
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    Thesis Type
    Thesis (Masters)
    Degree Program
    Master of Philosophy (MPhil)
    School
    School of Pharmacy
    DOI
    https://doi.org/10.25904/1912/327
    Copyright Statement
    The author owns the copyright in this thesis, unless stated otherwise.
    Item Access Status
    Public
    Subject
    a-Tocopheryl Succinate
    in-vitro Franz diffusion cell
    Vitamin E
    Publication URI
    http://hdl.handle.net/10072/365909
    Collection
    • Theses - Higher Degree by Research

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