Formulation and Investigation of Specialised Dosage Forms for the Systematic Delivery of the Selective Antineoplastic a-Tocopheryl Succinate

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Author(s)
Primary Supervisor
Grant, Gary
Other Supervisors
Chan, Yiu-Ngok
Neuzil, Jiri
Year published
2011
Metadata
Show full item recordAbstract
Background.
a-Tocopheryl succinate, a redox-silent analogue of vitamin E, has been shown to selectively induce apoptosis in a variety of cancers. However, a-tocopheryl succinate is rendered ineffective when administered orally due to hepatic metabolism. Transdermal delivery has been identified as an alternative approach for delivering in-tact a-tocopheryl succinate systemically.
Aims and objectives.
The aim of this study was to compound a liposomal formulation of a-tocopheryl succinate and evaluate the transdermal diffusion in an in-vitro Franz diffusion cell assay. The feasibility of transdermal delivery was further evaluated ...
View more >Background. a-Tocopheryl succinate, a redox-silent analogue of vitamin E, has been shown to selectively induce apoptosis in a variety of cancers. However, a-tocopheryl succinate is rendered ineffective when administered orally due to hepatic metabolism. Transdermal delivery has been identified as an alternative approach for delivering in-tact a-tocopheryl succinate systemically. Aims and objectives. The aim of this study was to compound a liposomal formulation of a-tocopheryl succinate and evaluate the transdermal diffusion in an in-vitro Franz diffusion cell assay. The feasibility of transdermal delivery was further evaluated by studying the potential metabolism of a-tocopheryl succinate by esterases, which are commonly located in the skin. Methods. Large quantities of a-tocopheryl succinate was sourced and characterised by nuclear magnetic resonance, mass spectrometry, infrared spectroscopy and differential scanning calorimetry for the compounding of transdermal dosage forms. Analytical high performance liquid chromatography and extraction methods were developed and validated to isolate, identify and quantify a-tocopheryl succinate.
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View more >Background. a-Tocopheryl succinate, a redox-silent analogue of vitamin E, has been shown to selectively induce apoptosis in a variety of cancers. However, a-tocopheryl succinate is rendered ineffective when administered orally due to hepatic metabolism. Transdermal delivery has been identified as an alternative approach for delivering in-tact a-tocopheryl succinate systemically. Aims and objectives. The aim of this study was to compound a liposomal formulation of a-tocopheryl succinate and evaluate the transdermal diffusion in an in-vitro Franz diffusion cell assay. The feasibility of transdermal delivery was further evaluated by studying the potential metabolism of a-tocopheryl succinate by esterases, which are commonly located in the skin. Methods. Large quantities of a-tocopheryl succinate was sourced and characterised by nuclear magnetic resonance, mass spectrometry, infrared spectroscopy and differential scanning calorimetry for the compounding of transdermal dosage forms. Analytical high performance liquid chromatography and extraction methods were developed and validated to isolate, identify and quantify a-tocopheryl succinate.
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Thesis Type
Thesis (Masters)
Degree Program
Master of Philosophy (MPhil)
School
School of Pharmacy
Copyright Statement
The author owns the copyright in this thesis, unless stated otherwise.
Item Access Status
Public
Subject
a-Tocopheryl Succinate
in-vitro Franz diffusion cell
Vitamin E