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dc.contributor.advisorGrant, Gary
dc.contributor.authorSeshadri, Madhumathi
dc.date.accessioned2018-01-23T02:23:55Z
dc.date.available2018-01-23T02:23:55Z
dc.date.issued2011
dc.identifier.doi10.25904/1912/327
dc.identifier.urihttp://hdl.handle.net/10072/365909
dc.description.abstractBackground. a-Tocopheryl succinate, a redox-silent analogue of vitamin E, has been shown to selectively induce apoptosis in a variety of cancers. However, a-tocopheryl succinate is rendered ineffective when administered orally due to hepatic metabolism. Transdermal delivery has been identified as an alternative approach for delivering in-tact a-tocopheryl succinate systemically. Aims and objectives. The aim of this study was to compound a liposomal formulation of a-tocopheryl succinate and evaluate the transdermal diffusion in an in-vitro Franz diffusion cell assay. The feasibility of transdermal delivery was further evaluated by studying the potential metabolism of a-tocopheryl succinate by esterases, which are commonly located in the skin. Methods. Large quantities of a-tocopheryl succinate was sourced and characterised by nuclear magnetic resonance, mass spectrometry, infrared spectroscopy and differential scanning calorimetry for the compounding of transdermal dosage forms. Analytical high performance liquid chromatography and extraction methods were developed and validated to isolate, identify and quantify a-tocopheryl succinate.
dc.languageEnglish
dc.publisherGriffith University
dc.publisher.placeBrisbane
dc.rights.copyrightThe author owns the copyright in this thesis, unless stated otherwise.
dc.subject.keywordsa-Tocopheryl Succinate
dc.subject.keywordsin-vitro Franz diffusion cell
dc.subject.keywordsVitamin E
dc.titleFormulation and Investigation of Specialised Dosage Forms for the Systematic Delivery of the Selective Antineoplastic a-Tocopheryl Succinate
dc.typeGriffith thesis
gro.facultyGriffith Health
gro.rights.copyrightThe author owns the copyright in this thesis, unless stated otherwise.
gro.hasfulltextFull Text
dc.contributor.otheradvisorChan, Yiu-Ngok
dc.contributor.otheradvisorNeuzil, Jiri
dc.rights.accessRightsPublic
gro.identifier.gurtIDgu1344302424925
gro.source.ADTshelfnoADT0
gro.source.GURTshelfnoGURT1284
gro.thesis.degreelevelThesis (Masters)
gro.thesis.degreeprogramMaster of Philosophy (MPhil)
gro.departmentSchool of Pharmacy
gro.griffith.authorSeshadri, Madhumathi


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