The Total Synthesis of the Anti-Austerity Agents (+/-) – Nicolaioidesin B, Analogues of Angelmarin and the Preparation of 2,5 –dimethoxy – 4 Iodo phenyl cyclopopylamine, a Serotonin Receptor Agonist
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Author(s)
Primary Supervisor
Coster, Mark
Other Supervisors
Jenkins, Ian
Nichols, David
Year published
2013
Metadata
Show full item recordAbstract
Pancreatic
Cancer
is
a
serious
health
problem
in
developed
countries.
Each
year
over
600,000
people
die
worldwide
as
a
result
of
the
disease.1
Pancreatic
cancer
has
the
highest
fatality
rate
of
all
cancers
with
5‐year
survival
rates
less
than
5%.2
In
the
early
stages
of
pancreatic
cancer
symptoms
are
difficult
to
observe,
leading
to
locally
advanced
or
metastatic
disease
at
time
of
diagnosis.3
Current
treatment
strategies
include
chemotherapy,
radiation
and
pancreatectomy,
a
surgical
procedure
to
remove
affected
parts
of
the
pancreas.4
These
commonly
have
little
...
View more >Pancreatic Cancer is a serious health problem in developed countries. Each year over 600,000 people die worldwide as a result of the disease.1 Pancreatic cancer has the highest fatality rate of all cancers with 5‐year survival rates less than 5%.2 In the early stages of pancreatic cancer symptoms are difficult to observe, leading to locally advanced or metastatic disease at time of diagnosis.3 Current treatment strategies include chemotherapy, radiation and pancreatectomy, a surgical procedure to remove affected parts of the pancreas.4 These commonly have little effect on progression of the disease and typically only extend the lives of patients by a matter of weeks or months.4 The median survival time from diagnosis of affected individuals is 4‐6 months.5 Despite recent advances made in treatment of many cancers, the outlook for patients suffering from pancreatic cancer has not improved in over 3 decades.2 Although no clinically effective therapeutics exist to date, advances in our understanding of pancreatic cancer biology has led to the recognition of novel targets for potential cancer therapies. One such potential therapeutic strategy is the ‘anti‐ austerity’ approach to the treatment of pancreatic cancer.
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View more >Pancreatic Cancer is a serious health problem in developed countries. Each year over 600,000 people die worldwide as a result of the disease.1 Pancreatic cancer has the highest fatality rate of all cancers with 5‐year survival rates less than 5%.2 In the early stages of pancreatic cancer symptoms are difficult to observe, leading to locally advanced or metastatic disease at time of diagnosis.3 Current treatment strategies include chemotherapy, radiation and pancreatectomy, a surgical procedure to remove affected parts of the pancreas.4 These commonly have little effect on progression of the disease and typically only extend the lives of patients by a matter of weeks or months.4 The median survival time from diagnosis of affected individuals is 4‐6 months.5 Despite recent advances made in treatment of many cancers, the outlook for patients suffering from pancreatic cancer has not improved in over 3 decades.2 Although no clinically effective therapeutics exist to date, advances in our understanding of pancreatic cancer biology has led to the recognition of novel targets for potential cancer therapies. One such potential therapeutic strategy is the ‘anti‐ austerity’ approach to the treatment of pancreatic cancer.
View less >
Thesis Type
Thesis (PhD Doctorate)
Degree Program
Doctor of Philosophy (PhD)
School
Eskitis Institute for Cell and Molecular Therapies
Copyright Statement
The author owns the copyright in this thesis, unless stated otherwise.
Item Access Status
Public
Note
The Title page and front pages were missing from the digital copy supplied by the Candidate.
Subject
Pancreatic cancer
Nicolaioidesin B
Angelmarin