The Total Synthesis of the Anti-Austerity Agents (+/-) – Nicolaioidesin B, Analogues of Angelmarin and the Preparation of 2,5 –dimethoxy – 4 Iodo phenyl cyclopopylamine, a Serotonin Receptor Agonist
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Pancreatic Cancer is a serious health problem in developed countries. Each year over 600,000 people die worldwide as a result of the disease.1 Pancreatic cancer has the highest fatality rate of all cancers with 5‐year survival rates less than 5%.2 In the early stages of pancreatic cancer symptoms are difficult to observe, leading to locally advanced or metastatic disease at time of diagnosis.3 Current treatment strategies include chemotherapy, radiation and pancreatectomy, a surgical procedure to remove affected parts of the pancreas.4 These commonly have little effect on progression of the disease and typically only extend the lives of patients by a matter of weeks or months.4 The median survival time from diagnosis of affected individuals is 4‐6 months.5 Despite recent advances made in treatment of many cancers, the outlook for patients suffering from pancreatic cancer has not improved in over 3 decades.2 Although no clinically effective therapeutics exist to date, advances in our understanding of pancreatic cancer biology has led to the recognition of novel targets for potential cancer therapies. One such potential therapeutic strategy is the ‘anti‐ austerity’ approach to the treatment of pancreatic cancer.
Thesis (PhD Doctorate)
Doctor of Philosophy (PhD)
Eskitis Institute for Cell and Molecular Therapies
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