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  • Structural Insights into Glycan Interactions of Human Pathogens

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    Bohm_2014_01Thesis.pdf (38.38Mb)
    Author(s)
    Bohm, Raphael
    Primary Supervisor
    Itzstein, Mark von
    Other Supervisors
    Dyason, Jeffrey
    Haselhorst, Thomas
    Year published
    2014
    Metadata
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    Abstract
    Glycans are major components of every cell surface. In addition to their importance in many physiological processes, glycans play a key role during infection of many pathogens. The identification and characterisation of glycan-pathogen interactions at a molecular and atomic level is therefore a crucial step towards the design of novel antimicrobial drugs and vaccines. Protein functions related to glycan interactions include glycan biosynthesis (glycosyltransferases), glycan recognition (lectins) and glycan degradation (glycosylhydrolases). This thesis investigates structure-function relationships of four glycan ...
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    Glycans are major components of every cell surface. In addition to their importance in many physiological processes, glycans play a key role during infection of many pathogens. The identification and characterisation of glycan-pathogen interactions at a molecular and atomic level is therefore a crucial step towards the design of novel antimicrobial drugs and vaccines. Protein functions related to glycan interactions include glycan biosynthesis (glycosyltransferases), glycan recognition (lectins) and glycan degradation (glycosylhydrolases). This thesis investigates structure-function relationships of four glycan binding proteins that are important for the infectivity of three major human pathogens: the polysialyltransferase (polyST) of Neisseria meningitidis serogroup B (NmB), the viral protein 8* (VP8*) of rotavirus, and the hemagglutinin (HA) and the neuraminidase (NA) of influenza A virus (IAV).
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    Thesis Type
    Thesis (PhD Doctorate)
    Degree Program
    Doctor of Philosophy (PhD)
    School
    Institute for Glycomics
    DOI
    https://doi.org/10.25904/1912/3321
    Copyright Statement
    The author owns the copyright in this thesis, unless stated otherwise.
    Item Access Status
    Public
    Subject
    Glycans
    Human pathogens
    Glycan biosynthesis (glycosyltransferases)
    Glycan recognition (lectins)
    Glycan degradation (glycosylhydrolases)
    Publication URI
    http://hdl.handle.net/10072/366018
    Collection
    • Theses - Higher Degree by Research

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