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  • Protective Effects of Caffeine and Coffee Constituents in Inflammatory Models of Depression

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    Hall,S_2016_01Thesis.pdf (3.681Mb)
    Author(s)
    Hall, Susan
    Primary Supervisor
    Grant, Gary
    Kiefel, Milton
    Other Supervisors
    McDermott, Catherine
    Arora, Devinder
    Year published
    2016
    Metadata
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    Abstract
    Caffeine is the most widely used compound that exerts a pharmacological effect on the central nervous system and is found most predominantly in coffee. It has been well established that coffee has a beneficial effect on numerous disease states including depression. A number of prospective and cohort studies have shown the benefit of coffee in preventing episodes of depressive symptoms. Studies indicate that the amount of coffee consumed is important with studies showing that moderate intake of caffeinated coffee may be beneficial in decreasing the risk of developing symptoms of clinical depression. It has however been shown ...
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    Caffeine is the most widely used compound that exerts a pharmacological effect on the central nervous system and is found most predominantly in coffee. It has been well established that coffee has a beneficial effect on numerous disease states including depression. A number of prospective and cohort studies have shown the benefit of coffee in preventing episodes of depressive symptoms. Studies indicate that the amount of coffee consumed is important with studies showing that moderate intake of caffeinated coffee may be beneficial in decreasing the risk of developing symptoms of clinical depression. It has however been shown that high consumption of coffee increases the risk of depression and suicide. It appears that caffeine in combination with other constituents of coffee may be required to show the antidepressant activity. To date very few studies have been undertaken to evaluate components of coffee for their antidepressant effects and no studies have been undertaken assessing these compounds in combination with caffeine and their subsequent effects on symptoms of depression. Over the last 50 years there have been countless proposed hypotheses of depression many of which are flawed including the well-accepted monoamine theory of depression. As a result of the shortcomings identified in this theory, numerous newer theories of depression have been proposed in recent times.
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    Thesis Type
    Thesis (PhD Doctorate)
    Degree Program
    Doctor of Philosophy (PhD)
    School
    School of Pharmacy
    DOI
    https://doi.org/10.25904/1912/3351
    Copyright Statement
    The author owns the copyright in this thesis, unless stated otherwise.
    Item Access Status
    Public
    Subject
    Caffeine, Therapeutic uses
    Coffee, Therapeutic uses
    Depression
    Publication URI
    http://hdl.handle.net/10072/366024
    Collection
    • Theses - Higher Degree by Research

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