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dc.contributor.advisorLam, Alfred
dc.contributor.authorRahman, Md. Atiquren_US
dc.date.accessioned2018-01-23T02:25:10Z
dc.date.available2018-01-23T02:25:10Z
dc.date.issued2016en_US
dc.identifier.urihttp://hdl.handle.net/10072/366030
dc.description.abstractCancer is a disease driven by complex genetic abnormalities. The ultimate outcome of these complex genetic disorders is uncontrolled cell proliferation. There are two major cellular proliferation and survival signalling pathways which are RAS-RAF- MEK-ERK and PI3K-AKT-mTOR proliferation-survival pathways. These proliferation-survival cell signalling pathways receive, carry and transfer important cell signals to the nucleus where the major transcription changes required for cell proliferation and survival occur. In normal cells, this proliferation cell signalling process is controlled, but this process becomes uncontrolled in cancer cells due to complex genetic changes like genetic mutations. One such genetic mutation is the BRAF V600E mutation which transforms the BRAF kinase into an auto-activated kinase. As a result, the RAS-RAF-MEK-ERK proliferation-survival pathway becomes truncated and auto-activated BRAF kinase continuously sends proliferation-survival signals to the nucleus through downstream MEK-ERK signalling molecules. Therefore, BRAF V600E mutated cells proliferate without control, invade & damage surrounding tissues and metastasise all over the body.en_US
dc.languageEnglishen_US
dc.publisherGriffith Universityen_US
dc.publisher.placeBrisbaneen_US
dc.rights.copyrightThe author owns the copyright in this thesis, unless stated otherwise.en_US
dc.subject.keywordsCanceren_US
dc.subject.keywordsProliferation-survival cell signalling pathwaysen_US
dc.subject.keywordsGenetic abnormalitiesen_US
dc.titleAlternative Approach to Proliferation Pathway Suppression in Human Cancersen_US
dc.typeGriffith thesisen_US
gro.facultyGriffith Healthen_US
gro.hasfulltextFull Text
dc.contributor.otheradvisorSmith, Robert
dc.contributor.otheradvisorAriana, Armin
dc.rights.accessRightsPublicen_US
gro.identifier.gurtIDgu1487737874284en_US
gro.thesis.degreelevelThesis (PhD Doctorate)en_US
gro.thesis.degreeprogramDoctor of Philosophy (PhD)en_US
gro.departmentSchool of Medical Scienceen_US
gro.griffith.authorRahman, Md. Atiqur A.


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