Dengue Virus Infection of Human Microvascular Endothelial Cells
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Dengue virus (DENV) infection is an important public health problem, being globally the most highly prevalent mosquito-borne viral illness. The World Health Organization (WHO) has estimated 2.5 billion people are at risk of DENV infection and each year 50- 100 million infections are reported, with over 500,000 hospitalisations and 25,000 deaths. DENV consist of four serotypes, each of which are capable of producing a wide spectrum of syndromes varying from mild dengue fever (DF) to more severe dengue haemorrhagic fever (DHF). Vascular leakage resulting from increased micro vessel endothelial permeability is one of the life-threatening complications in DHF. The relationship between DENV infection and the endothelium has previously been investigated both in vitro and in vivo experiments. Nevertheless, the mechanisms by which dengue infection leads to increased vascular permeability remain unclear. Understanding the underlying mechanisms of vascular leakage is required to identify better control strategies for DHF/DSS.
Thesis (PhD Doctorate)
Doctor of Philosophy (PhD)
Institute for Glycomics
Item Access Status
Microvascular endothelial cells