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dc.contributor.advisorMahalingam, Suresh
dc.contributor.authorObeysekera, Maheshi Prabodanien_US
dc.date.accessioned2018-01-23T02:25:10Z
dc.date.available2018-01-23T02:25:10Z
dc.date.issued2016en_US
dc.identifier.doi10.25904/1912/2817
dc.identifier.urihttp://hdl.handle.net/10072/366032
dc.description.abstractDengue virus (DENV) infection is an important public health problem, being globally the most highly prevalent mosquito-borne viral illness. The World Health Organization (WHO) has estimated 2.5 billion people are at risk of DENV infection and each year 50- 100 million infections are reported, with over 500,000 hospitalisations and 25,000 deaths. DENV consist of four serotypes, each of which are capable of producing a wide spectrum of syndromes varying from mild dengue fever (DF) to more severe dengue haemorrhagic fever (DHF). Vascular leakage resulting from increased micro vessel endothelial permeability is one of the life-threatening complications in DHF. The relationship between DENV infection and the endothelium has previously been investigated both in vitro and in vivo experiments. Nevertheless, the mechanisms by which dengue infection leads to increased vascular permeability remain unclear. Understanding the underlying mechanisms of vascular leakage is required to identify better control strategies for DHF/DSS.en_US
dc.languageEnglishen_US
dc.publisherGriffith Universityen_US
dc.publisher.placeBrisbaneen_US
dc.rights.copyrightThe author owns the copyright in this thesis, unless stated otherwise.en_US
dc.subject.keywordsDengue virusen_US
dc.subject.keywordsVascular leakageen_US
dc.subject.keywordsEndothelial permeabilityen_US
dc.subject.keywordsMicrovascular endothelial cellsen_US
dc.titleDengue Virus Infection of Human Microvascular Endothelial Cellsen_US
dc.typeGriffith thesisen_US
gro.facultyScience, Environment, Engineering and Technologyen_US
gro.rights.copyrightThe author owns the copyright in this thesis, unless stated otherwise.
gro.hasfulltextFull Text
dc.contributor.otheradvisorHerrero, Lara
dc.contributor.otheradvisorHerring, Belinda
dc.rights.accessRightsPublicen_US
gro.identifier.gurtIDgu1488344102130en_US
gro.thesis.degreelevelThesis (PhD Doctorate)en_US
gro.thesis.degreeprogramDoctor of Philosophy (PhD)en_US
gro.departmentInstitute for Glycomicsen_US
gro.griffith.authorObeysekera, Maheshi Prabodani


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