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  • Role of Full and Partial Adenosine Receptor Agonists in the Cardiac Myocyte

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    Butcher_2012_02Thesis.pdf (3.328Mb)
    Author(s)
    Butcher, Anna
    Primary Supervisor
    Rose'meyer, Roselyn
    Other Supervisors
    Neuzil, Jiri
    Year published
    2012
    Metadata
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    Abstract
    Cardiovascular disease remains one of the largest health burdens facing the westernised world. The ubiquitous nucleoside, adenosine and its accompanying receptors may have beneficial effects in the treatment of ischaemic heart disease. Adenosine is derived from the catabolism of ATP and has long been considered a potent bradycardic and hypotensive compound. For over half a century, adenosine and its analogues have often been considered potential cardioprotective drug targets. These protective effects are mediated via the action of adenosine receptors: ADORA1, ADORA2A, ADORA2B and ADORA3. The main purpose of this thesis was ...
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    Cardiovascular disease remains one of the largest health burdens facing the westernised world. The ubiquitous nucleoside, adenosine and its accompanying receptors may have beneficial effects in the treatment of ischaemic heart disease. Adenosine is derived from the catabolism of ATP and has long been considered a potent bradycardic and hypotensive compound. For over half a century, adenosine and its analogues have often been considered potential cardioprotective drug targets. These protective effects are mediated via the action of adenosine receptors: ADORA1, ADORA2A, ADORA2B and ADORA3. The main purpose of this thesis was to examine the role and mechanisms of selective adenosine full and partial agonists in the ischaemic-reperfused mouse heart, exploring the potential cellular mechanisms involved in cardiomyocyte cell death, functional parameters and pharmacological manipulation of the recovering heart. The effects of enhancing endogenous adenosine activation through the use of allosteric enhancers are also assessed.
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    Thesis Type
    Thesis (PhD Doctorate)
    Degree Program
    Doctor of Philosophy (PhD)
    School
    School of Medical Science
    DOI
    https://doi.org/10.25904/1912/1999
    Copyright Statement
    The author owns the copyright in this thesis, unless stated otherwise.
    Item Access Status
    Public
    Subject
    Cardiovascular disease
    Ischaemic heart disease
    Adenosine receptor
    Cardiac myocyte
    Publication URI
    http://hdl.handle.net/10072/366145
    Collection
    • Theses - Higher Degree by Research

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