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dc.contributor.advisorCoster, Mark
dc.contributor.authorO'Connor, Sean M. J.en_US
dc.date.accessioned2018-01-23T02:27:37Z
dc.date.available2018-01-23T02:27:37Z
dc.date.issued2012en_US
dc.identifier.doi10.25904/1912/3472
dc.identifier.urihttp://hdl.handle.net/10072/366217
dc.description.abstractThis thesis describes the synthetic studies performed utilizing tridentate Schiff base Cr(III) complex catalysts towards the total synthesis of ()-lasonolide A resulting in the completion of synthetic efforts towards the C17-C25 segment. Further summarization is also given on completion of the C7-C16 segment and an overview of future directions toward to the total synthesis of ()-lasonolide A. Both tetrahydropyrans C7-C11 and C19-C23 were to be constructed utilising an asymmetric hetero-Diels–Alder protocol involving Jacobsen’s hetero-Diels–Alder catalyst providing a means to generate a number of the desired stereocentres simultaneously in each ring system, followed by novel macrolide formation using ruthenium catalysts for metathesis olefination and Alder-ene chemistry. Jacobsen's hetero-Diels–Alder catalyst has also been utilised to generate C-disacharide linked precursors under diastereolective control in an effort to generate stereospecific 13 linked disaccharides.en_US
dc.languageEnglishen_US
dc.publisherGriffith Universityen_US
dc.publisher.placeBrisbaneen_US
dc.rights.copyrightThe author owns the copyright in this thesis, unless stated otherwise.en_US
dc.subject.keywordsTridentate Schiff base Cr (III)en_US
dc.subject.keywordsTetrahydropyransen_US
dc.subject.keywordsJacobsen's hetero-Diels–Alder catalysten_US
dc.subject.keywordsLasonolide Aen_US
dc.subject.keywordsPancreatic canceren_US
dc.titleApplication of Tridentate Schiff Base Chromium (III) Complex Catalysts Towards the Total Synthesis of (-)- Lasonolide A and C-Disaccharide Mimicsen_US
dc.typeGriffith thesisen_US
gro.facultyScience, Environment, Engineering and Technologyen_US
gro.rights.copyrightThe author owns the copyright in this thesis, unless stated otherwise.
gro.hasfulltextFull Text
dc.contributor.otheradvisorQuinn, Ron
dc.rights.accessRightsPublicen_US
gro.identifier.gurtIDgu1357184856112en_US
gro.source.ADTshelfnoADT0en_US
gro.source.GURTshelfnoGURT1343en_US
gro.thesis.degreelevelThesis (PhD Doctorate)en_US
gro.thesis.degreeprogramDoctor of Philosophy (PhD)en_US
gro.departmentSchool of Biomolecular and Physical Sciencesen_US
gro.griffith.authorO'Connor, Sean M. J.


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