The Potential Role of GATA4, ESR1, GRIA3 and SCN1A Genes in Migraine Susceptibility
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Migraine is a common and painful neurological disorder, with genetic and environmental components. The prevalence of migraine varies between different racial groups, being higher in Caucasian populations (12%). Several conditions have been shown to be comorbid with migraine. One heart disorder that has been associated with migraine is a cardiac malformation affecting the interatrial septum and leading to patent foramen ovale (PFO), resulting from an incomplete anatomic fusion of the atrial septum primum and secundum. Mutations in the development regulatory gene GATA-4, located on human chromosome 8p23.1-p22, have been found to be responsible for some cases of congenital heart defects including PFO. To determine whether the GATA-4 gene is involved in migraine, the present study performed an association analysis of a common GATA-4 variant that results in a change of amino acid (S377G), in a large case/control population (275 unrelated Caucasian migraineurs versus 275 control individuals). Samples were genotyped for the single nucleotide polymorphism (SNP) using FACSArray flow cytometer and frequencies for this variant compared in migraine cases and age, sex and ethnicity matched controls...
Master of Philosophy (MPhil)
School of Medical Science
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polygenic multifactorial disease